Health

FDA issues vouchers to 3 companies to help fast track review of potential psychedelic medications

Psilocybin mushrooms stand ready for harvest in a humidified “fruiting chamber” in the basement of a private home on July 28, 2023 in Fairfield County, Connecticut. (John Moore/Getty Images)

(NEW YORK) — The Food and Drug Administration (FDA) announced on Friday It’s issuing national priority vouchers to three companies to help fast-track the review of certain psychedelic medications.

The companies are studying psilocybin for treatment-resistant depression and major depressive disorder and methylone for post-traumatic stress disorder (PTSD).

These vouchers mean the FDA has 60 days to review the medications for approval. 

“These medications have the potential to address the nation’s mental health crisis, including conditions like treatment-resistant depression, alcoholism and other serious mental health and substance abuse conditions,” FDA Commissioner Dr. Marty Makary said in a press release.

“As this field moves forward, it is critical that their development is grounded in sound science and rigorous clinical evidence,” the statement continued. “We owe it to our nation’s veterans and all Americans who are suffering from these conditions to evaluate these potential therapies with urgency.”

The agency also announced it is allowing an early phase clinical study of noribogaine hydrochloride, the principal psychoactive substance of the drug ibogaine, to move forward following an Investigational New Drug submission.

This is the first time the FDA has allowed a clinical study in the U.S. of a derivative of ibogaine, which is derived from the African Tabernanthe iboga shrub, the press release said.

Noribogaine hydrochloride is being investigated as a potential treatment for alochol use disorder, according the FDA.

The FDA also said it intends “to release final guidance imminently to provide recommendations to sponsors developing these products” which will include recommendations for study design, data collection and patient monitoring.

“There is a growing recognition of the potential of psychedelic medications to address multiple different psychiatric conditions that are notoriously difficult to treat,” said Dr. Tracy Beth Hoeg, acting director of the FDA’s Center for Drug Evaluation and Research. “At the FDA we are showing our support of investigating the safety and efficacy of this class of drugs through today’s actions.”

The announcement comes after President Donald Trump signed an executive order over the weekend directing the FDA to expedite its review of certain psychedelics.

The order aims to accelerate research and approval of psychedelic-based therapies to help treat mental health conditions including PTSD, depression and addiction.

Currently, there are no classic psychedelic drugs approved for routine psychiatric care in the U.S.

A multitude of studies have suggested that psychoactive drugs, including cannabis, ketamine, psilocybin and midomafetamine (MDMA), may help treat PTSD and other mental health disorders.

However, most of these drugs are classified as Schedule I, meaning they have “no currently accepted medical use and a high potential for abuse,” according to the Drug Enforcement Administration.

A 24-person 2022 study from John Hopkins Medicine followed patients with moderate to severe major depressive disorder who received psilocybin-assisted treatment for up to a year. Psilocybin is the main psychoactive ingredient in magic mushrooms.

Researchers found antidepressant effects from psilocybin and supportive psychotherapy may last at least a year in some patients. Administration required close monitoring in a controlled setting with a trained provider. 

MDMA has shown some early promise in treating PTSD. However, in June 2024, a panel of independent advisers for the FDA voted against recommending approval of pharmaceutical version of MDMA — along with therapy — to treat the condition.

The Psychopharmacologic Drugs Advisory Committee appeared to have doubts about the safety and efficacy of the treatment, with the majority voting “no” on questions of data showing the drug is effective and that the benefits of MDMA outweigh the risks for the treatment of patients with PTSD.

Methylone is a synthetic stimulant related to MDMA that affects mood and energy but carries risks of addiction, heart strain, and other serious side effects.

ABC News’ Liz Neporent contributed to this report.

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Entertainment

Rob and Michele Reiner’s son Jake Reiner speaks out in heartbreaking statement: ‘My living nightmare’

Jake Reiner, Romy Reiner, Rob Reiner, and Michele Reiner attend the 75th Primetime Emmy Awards at Peacock Theater on January 15, 2024 in Los Angeles, California. (Neilson Barnard/Getty Images)

Jake Reiner, the eldest son of renowned director Rob Reiner and his wife Michele Reiner, is speaking out in a rare statement, saying, “I still wake up every morning having to convince myself that, no, it’s not a dream.”

“This truly is my living nightmare,” he said in a post on Substack on Friday.

“One thing I keep coming back to is how frightened they must have been,” Jake Reiner said of his parents. “They were the last people in the world to deserve what happened to them. They deserved to be loved, they deserved to be respected, and above all they deserved to be appreciated for how much they gave to all three of us and to the world.”

Jake Reiner’s brother, Nick Reiner, has pleaded not guilty to murder charges for the deaths of their parents and is due back in court next week.

Rob Reiner and Michele Reiner were found stabbed to death in their Brentwood home on Dec. 14, 2025. The night before, Nick Reiner — who had been living on his parents’ property — got into an argument with Rob Reiner at a holiday party and was seen acting strangely, sources told ABC News. Nick Reiner was taken into custody hours after the bodies were discovered.

Rob Reiner, 78, and Michele Reiner, 68, married in 1989 and had three children: sons Jake and Nick and daughter Romy.

Jake Reiner described his parents as his “guiding lights, the foundation of who I am as a human being, and the most giving people I have ever known.”

“The love they have for me, my brother, and my sister is truly unconditional. And the love they have for each other in their marriage is something I always looked up to as the standard of what a successful relationship looks like,” he wrote.

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National

New England Patriots coach Mike Vrabel says his recent actions have not met his ‘standard’

: Mike Vrabel of the New England Patriots speaks to the media during the 2026 NFL Scouting Combine at Lucas Oil Stadium on February 25, 2026 in Indianapolis, Indiana. (Photo by Lauren Leigh Bacho/Getty Images)

(NEW YORK) — The New England Patriots head coach, Mike Vrabel, addressed the media Thursday after a series of photos were published allegedly showing him with former Athletic reporter Dianna Russini.

In his remarks, Vrabel said that his “actions don’t meet the standard I hold myself to” and his initial response to the pictures was an attempt to protect his family, saying that the photos showed an innocent interaction.

“I just know I’m going to take the necessary steps with the people I care about — that’s my family and this team,” said Vrabel.

Vrabel and Russini are both married to other people. Russini resigned from The Athletic on April 14.

“I have no interest in submitting to a public inquiry that has already caused far more damage than I am willing to accept. Rather than allowing this to continue, I have decided to step aside now — before my current contract expires on June 30,” Russini wrote in her resignation letter. “I do so not because I accept the narrative that has been constructed around this episode, but because I refuse to lend it further oxygen or to let it define me or my career.”

Vrabel declined to comment on the most recent photos, saying “my priorities are my family and this football team. In that order,” according to ESPN.

Vrabel did confirm at a news conference Tuesday that he has had “difficult conversations with people I care about,” including his family, his coaching staff, team officials and players following the initial publication of the photos.

It is not clear if the New England Patriots will discipline Vrabel but NFL commissioner Roger Goodell told ESPN on Thursday that this is a team matter and does not fall under the league’s personal conduct policy.

“The New England Patriots fully support Mike Vrabel’s decision to prioritize his family first, as well as his own well-being,” the team said in a statement. “Mike has been open with us about his commitment to being the best version of himself for his family, this team and our fans, and we respect the steps he is taking to follow through on that commitment.”

Vrabel confirmed that he will start seeking counseling, saying “I can only say that whatever my family needs, that’s what I’m going to provide,” Vrabel said.

Copyright © 2026, ABC Audio. All rights reserved.

National

Rob and Michele Reiner’s son Jake Reiner speaks out in heartbreaking statement: ‘My living nightmare’

Jake Reiner, Romy Reiner, Rob Reiner, and Michele Reiner attend the 75th Primetime Emmy Awards at Peacock Theater on January 15, 2024 in Los Angeles, California. (Neilson Barnard/Getty Images)

(NEW YORK) — Jake Reiner, the eldest son of renowned director Rob Reiner and his wife Michele Reiner, is speaking out in a rare statement, saying, “I still wake up every morning having to convince myself that, no, it’s not a dream.”

“This truly is my living nightmare,” he said in a post on Substack on Friday.

“One thing I keep coming back to is how frightened they must have been,” Jake Reiner said of his parents. “They were the last people in the world to deserve what happened to them. They deserved to be loved, they deserved to be respected, and above all they deserved to be appreciated for how much they gave to all three of us and to the world.”

Jake Reiner’s brother, Nick Reiner, has pleaded not guilty to murder charges for the deaths of their parents and is due back in court next week.

Rob Reiner and Michele Reiner were found stabbed to death in their Brentwood home on Dec. 14, 2025. The night before, Nick Reiner — who had been living on his parents’ property — got into an argument with Rob Reiner at a holiday party and was seen acting strangely, sources told ABC News. Nick Reiner was taken into custody hours after the bodies were discovered.

Rob Reiner, 78, and Michele Reiner, 68, married in 1989 and had three children: sons Jake and Nick and daughter Romy.

Jake Reiner described his parents as his “guiding lights, the foundation of who I am as a human being, and the most giving people I have ever known.”

“The love they have for me, my brother, and my sister is truly unconditional. And the love they have for each other in their marriage is something I always looked up to as the standard of what a successful relationship looks like,” he wrote.

Jake Reiner called his mom his “confidant” and said they could talk for hours.

“Anytime I was going through a tough time or had a complicated issue to hash out, I leaned on her brilliant perspective,” he wrote.

“My mom was the one who helped me move in and out of dorms and apartments at Syracuse University and continued to help me move in and out of apartments when I began my broadcasting career,” he said. “Her support for me never wavered, and I always felt how much she loved me. I feel her presence everywhere, every single day. I miss her so much.”

Jake Reiner said his father — the famed director, producer and actor known for massive Hollywood hits including “The Princess Bride” and “When Harry Met Sally…” – was the same way at home and in public.

This is a developing story. Please check back for updates.

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National

Enid, Oklahoma, surveys damage after massive tornado tears through city

Severe weather map (ABC News)

(NEW YORK) — More than a dozen reported tornadoes tore through part of the Central U.S. on Thursday night, including a powerful storm in northwestern Oklahoma that spurred a tornado emergency from the National Weather Service.

A tornado emergency is the highest alert level for tornadoes.

The weather service said a “large and destructive tornado” was confirmed on the ground at 8:21 p.m. local time in the area of Enid, Oklahoma, near Vance Air Force Base, and urged residents to take cover.

“You are in a life-threatening situation,” the weather service said. “Flying debris may be deadly to those caught without shelter. Mobile homes will be destroyed. Considerable damage to homes, businesses, and vehicles is likely and complete destruction is possible.”

Enid, a city of roughly 50,000 people, is located about 90 miles north of Oklahoma City

Garfield County Sheriff Cory Rink told Oklahoma City ABC station KOCO that search-and-rescue operations were underway in “hard-hit” areas. He said he did not have word yet on any injuries.

A county emergency management official told KOCO there were reports of 10 to 11 people with minor injures and that the search and rescue operations in the Grayridge area was wrapping up.

Oklahoma Gov. Kevin Stitt, in a social media post, asked for prayers for the Enid community, which he said “has been severely impacted” by Thursday’s tornado.

“I have spoken with Enid’s local leaders and will continue working with them as they assess the damage and identify needs,” he said in the post.

Overall, there were 17 reported tornadoes Thursday night from Oklahoma to Iowa, and there were still several active tornado warnings along a line of dangerous storms stretching from Oklahoma to Missouri to Iowa.

Thursday is the first day of a multiday outbreak of severe weather for the Plains.

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National

Ex-assistant says she felt trapped in relationship with fired Michigan coach: ‘He knew he had power over me’

Paige Shiver speaks during an interview with ABC News’ Linsey Davis. (ABC News)

(NEW YORK) — Paige Shiver, a former executive assistant with the University of Michigan football team, said she felt that former head coach Sherrone Moore manipulated her during their nearly four-year relationship she characterized as an “open secret” within the athletics department.

Speaking out for the first time since Moore was arrested last December for trespassing, Shiver, 32, told ABC News that what started out as a consensual relationship became one in which she felt trapped over time. She said Moore, 40, told her he was in a loveless marriage and would soon divorce his wife, and that every time she tried to end the relationship, he would threaten suicide or plead with her not to leave.

Moore “had complete control over me, over my emotions, over my career, and he knew that, and he used it against me,” she said. “Every time I tried to pull away, every time I tried to get out of even Michigan, he always had a way to pull me in and make me feel that I couldn’t leave him because he was so miserable without me.”

Moore was sentenced to 18 months of probation this month after being fired for the relationship. He had faced a up to six months of jail time after pleading no contest to trespassing and malicious use of a telecommunications device. A felony home invasion charge was dropped as part of a plea deal.

The charges are related to a Dec. 10 incident in which Moore entered Shiver’s apartment the same day he was fired, according to police, who said he blamed Shiver for his firing and threatened to kill himself with butter knives. Shiver said she feared for her life and asked him repeatedly to leave.

“He’s six four and he comes in with his hood up, looking down at me, saying I ruined his life and is crying,” she said. “He’s not listening to me. And it’s like he knew he had control over me. He knew he had power over me.”

According to text messages Shiver shared with ABC News, Moore texted “I hate you” and “My blood is on your hands” to Shiver after the incident.

When asked for a response to Shiver’s account, Ellen Michaels, Moore’s attorney, said that “Sherrone Moore has closed this chapter.”

In response to a request for comment about Shiver’s claims, the university provided a statement, reading: “The University of Michigan terminated Sherrone Moore promptly upon discovering his undisclosed workplace relationship with a direct report. His conduct violated university policy, and we expect more from our leaders. The University of Michigan is committed to ensuring a professional and respectful workplace for all members of its community.”

In December, university President Domenico Grasso said the school was investigating the situation involving Moore “to uncover any additional germane and material information and to assess whether there may be related misconduct by others.”

Shiver started as an intern in the program in October 2021 and said her romantic relationship started months later in January 2022. She was promoted to be Moore’s executive assistant when he was promoted to head coach in 2024.

She described Moore during this time as emotionally dependent on her, a relationship she said the department encouraged.

She said she was often told by senior coaches to console Moore “to calm him down” when he was upset, sometimes during game halftimes. She said she went along with it because she feared for her job security. “No one cared about my feelings. They wanted to use me to help him so that they could get through the season,” she said.

“He and other coaches had control over my career, especially him. I mean, he could fire me in a second,” she said. “People knew, but no one was doing anything about it.”

In May 2022, during her relationship with Moore, Shiver said she discovered she was pregnant. At the time, she said her doctors advised she have an abortion to avoid complications from Pompe Disease, a rare and progressive disorder she was diagnosed with years earlier. Moore, Shiver said, told her she “had to do what’s right” for her body. She had the abortion that July.

Last October Shiver says she denied the relationship during an interview with the university human resources department.

She told ABC News that she didn’t disclose the relationship because she didn’t trust the process that she felt had protected Moore for years.

“They knew the things that he was doing to me and no one did anything about it because they cared more about winning football games, not having another scandal, and trying to protect the head coach,” she said.

She waited until December to tell attorneys hired by the university about the relationship.

Shiver is no longer employed by the University of Michigan. She said that, besides her disappointment with the university, she was disappointed that Moore only received probation.

“I don’t think it reflects what he did to me,” she said. “He took no accountability.”

If you are struggling with thoughts of suicide or worried about a friend or loved one, call or text the Suicide & Crisis Lifeline at 988 for free, confidential emotional support 24 hours a day, seven days a week.

Copyright © 2026, ABC Audio. All rights reserved.

National

1 dead, 5 suspects in custody in shooting at Mall of Louisiana: Police

Crime scene barrier tape (Getty Images/Tetra Images)

(BATON ROUGE, La.) — Five suspects are in custody in a shooting at the Mall of Louisiana in Baton Rouge that killed one person and injured multiple others, police said.

The shots were fired in the food court, police said, describing it as a targeted incident during a fight between two groups, and not a random act of violence.

Baton Rouge Police Chief T.J. Morse said during a press conference Thursday night that officials are looking for more suspects believed to be involved. “In no way is this investigation over, and we do believe that there’s more people involved,” he said.

Morse said one handgun has been recovered from the scene.

Five people injured in the shooting were being treated at area hospitals, according to Baton Rouge police. The nature of their injuries is unclear. Police had initially said 10 people were injured before updating the total number of casualties to six.

All shoppers have been evacuated from the mall, Baton Rouge Mayor-President Sid Edwards said.

The scene has been secured, police said.

“I heard a loud ‘pop’ and then another ‘pop,'” a mall employee told ABC Baton Rouge affiliate WBRZ. “… I turn around and I see people dropping to the floor and then I saw the gun. … And he was turning around, shooting randomly.”

“I called security and said, ‘Shots fired in the food court, people are down, people are hit.’ And then the cops came and it was just total chaos … blood was everywhere,” she said.

“I’ve never seen anything like this in my life,” she said.

Police Chief Morse said that officials believe the violence began after some kind of disagreement. “It looks like guns were pulled afterwards, exchanged right in front of some of the food counters in the food court,” he said.

Louisiana Gov. Jeff Landry said he’s aware of the shooting and is coordinating with law enforcement.

“Please keep the victims and their families in your prayers,” Edwards said in a statement.

Mayor Sid Edwards said during the press conference Thursday night that “Baton Rouge has a history of pulling together in tragedy, and that’s tragic unto itself.”

The Mall of Louisiana confirmed in a statement that it would be closed all day on Friday “out of respect for the victims.”

“Our deepest sympathies are with everyone who was impacted by the senseless act of violence that took place here today,” the statement read.

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Sports

Scoreboard roundup — 4/23/26

(NEW YORK) — Here are the scores from Thursday’s sports events:

NATIONAL BASKETBALL ASSOCIATION
Knicks 108, Hawks 109
Cavaliers 104, Raptors 126
Nuggets 96, Timberwolves 113

NATIONAL HOCKEY LEAGUE
Sabres 3, Bruins 1
Hurricanes 2, Senators 1
Avalanche 4, Kings 2

MAJOR LEAGUE BASEBALL
Braves 7, Nationals 2
Brewers 4, Tigers 5
Phillies 7, Cubs 8
Padres 10, Rockies 8
White Sox 4, Diamondbacks 1
Dodgers 3, Giants 0
Yankees 4, Red Sox 2
Twins 8, Mets 10
Pirates 1, Rangers 6

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Entertainment

In brief: ‘The Nanny Diaries’ TV series headed to Netflix and more

Scarlett Johansson is set to executive produce a TV adaptation of her film The Nanny Diaries. Deadline reports that Netflix is developing a series based on the film adaptation of Emma McLaughlin and Nicola Kraus’ book of the same name. Johansson starred as the titular nanny Annie alongside Laura Dern, Paul Giamatti, Alicia Keys and Chris Evans in the 2007 film …

Don’t miss the moment that The Moment makes its streaming debut. The A24 film will arrive to HBO Max on May 29. It will make its HBO linear debut on May 30. Charli XCX stars in the movie that is also based on her original idea. Rosanna Arquette, Kate Berlant, Jamie Demetriou, Hailey Benton Gates, Isaac Powell, Rish Shah and Alexander Skarsgård also star …

It seems many people have been watching Euphoria season 3. Variety reports that the second episode of the third season of HBO’s drama series hit 8.5 million viewers across both HBO and HBO Max in its first three days, according to numbers measured by Warner Bros. Discovery. This matches the viewership of the season 3 premiere …

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Entertainment

‘Euphoria’ star Adewale Akinnuoye-Agbaje on the ‘roller-coaster ride’ of season 3

Adewale Akinnuoye-Agbaje in ‘Euphoria’ season 3. (Eddy Chen/HBO)

Euphoria is so back.

Sam Levinson’s drama series has finally returned for season 3. Now that we’re two episodes into the third season, viewers are situated in the time jump and have met the many new characters who become part of Rue, Cassie, Nate, Maddy and Jules’ journey.

One of those new characters is Adewale Akinnuoye-Agbaje [ah’-duh-WAH-lay ah’-kuh-NO-yay ag-BAH-zhay]‘s Alamo, who is Rue’s (Zendaya) new boss. He spoke to ABC Audio about what it was like to join the series in its third season.

“It was really exciting to be invited and to be a part of the journey of Euphoria,” Akinnuoye-Agbaje said. “These performances of this young cast — Zendaya, Alexa Demie, Sydney Sweeney, Jacob Elordi — they were some of the most powerful performances I’ve seen on TV in many years. So the bar was set really high. And I was just happy to come on board and try to be a part of raising that bar.”

Akinnuoye-Agbaje continued, saying fans will be “taken on a roller-coaster ride” over the course of the season.

“We follow these characters that they’ve [grown] to love in high school into the real world and see the cost of some of the choices that they make dabbling on the wrong side of the law, which is the realm in which Alamo lives,” Akinnuoye-Agbaje says.

Above all else, Akinnuoye-Agbaje says season 3 continues to put a spotlight on one of the show’s main themes. 

“Most importantly, I think the subject matter that it addresses in this season, as it did in the previous ones, [is] the drug use and the impact of fentanyl on the younger generation,” Akinnuoye-Agbaje said. “It really does spotlight and highlight it in a real way, and I was happy to see that and be a part of that.”

New episodes of Euphoria air Sundays on HBO.

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