Supply chain issues hit hospitals, dialysis centers after Hurricane Helene
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(DURHAM, N.C.) — As hospitals and health care facilities work to get back up and running after Hurricane Helene slammed into Florida’s Big Bend, affecting several states, the medical supply chain could be at risk.
Baxter International, a health care and medical technology company, announced this week that it must close its largest plant in North Carolina due to flooding and destruction caused by the hurricane.
The plant, located in North Cove, 60 miles northeast of Asheville, primarily manufactures IV fluids and peritoneal dialysis solutions, according to Baxter. It is the largest manufacturer of such solutions in the U.S., employing more than 2,500 people, the company said.
“Our hearts and thoughts are with all those affected by Hurricane Helene,” José Almeida, chair, president and CEO of Baxter, said in a statement. “The safety of our employees, their families, and the communities in which we operate remains our utmost concern, and we are committed to helping ensure a reliable supply of products to patients.”
“Remediation efforts are already underway, and we will spare no resource – human or financial – to resume production and help ensure patients and providers have the products they need,” the statement continued.
Baxter said it implemented a hurricane preparedness plan ahead of Helene, which included evacuation plans for staff and moving products to higher ground or to secure storage. However, heavy rainfall and storm surge “triggered a levee breach,” which led to flooding in the facility.
Among those impacted by the Baxter plant closing is Duke University Health System (DUHS), in Durham, North Carolina, according to William Trophi, DUHS interim president vice president of supply chain.
“[Baxter has] published their action items, and they have announced to us that they’re putting a hold on all distribution for 48 hours to understand what they have in their supply line, and then they’re going to be setting up pretty strict allocations based on prior usage to make sure that everyone is getting their fair share based on their volume and their needs,” he told ABC News.
Trophi said DUHS and Duke University have not seen major disruption to their supply chain following Helene’s landfall, but notes there may be delays in the future if the Baxter plant closure lasts for several weeks, if more plants close, and depending on how long the dockworkers’ strike on the East Coast and the Gulf Coast lasts.
“What we’re doing internally is we’re looking at conservation models, so similar with our IV solutions, we’re going to look at what can we be doing differently to treat our patients in a safe, effective manner to conserve IV solutions,” he said. “And we’ll start to look at other high, critical, sensitive items that could be impacted by this, and look at what can we be doing differently to conserve the way in which we treat our patients in a safe, effective manner.”
Paul Biddinger, chief preparedness and continuity officer for the Boston-based Mass General Brigham health care system, told ABC News that facilities typically begin stockpiling and taking inventory of supplies prior to a natural disaster. After the event has happened, health care centers will work to identify what products are affected by supply chain issues and which patients are using the products.
In the case of the Baxter plant, the products are primarily used by kidney patients, cardiac patients and urologic patients, Biddinger said, adding that hospitals and other health care facilities will typically try to conserve as much of the affected product as possible, and will also investigate any alternatives or substitutions for the product.
“If the shortage is so severe that we just can’t continue with normal usage, even with conservation, then we have to start a process of allocating across our clinical services, of course, prioritizing lifesaving care and emergency care, and then going down our list for more scheduled or more elective kinds of procedures,” Biddinger said.
Samantha Penta, an associate professor of emergency management and homeland security at the University at Albany in New York, said one really important factor to consider when understanding the implications of Hurricane Helene is just how large the affected area is.
“We’re not just talking about a couple of counties. We’re not even just talking about one state. This has affected multiple states very significantly,” she told ABC News. “One of the things that organizations, in general, including hospitals, long-term care facilities and like – really, anything in the health care sector – does, is you can rely on neighboring facilities.”
Penta said if health care facilities need to send patients to a neighboring facility because they’re running low on supplies or space, or if their facility is damaged, they typically can do so. The same holds true if one facility is running low on supplies; another facility might send them some of their reserves as part of a mutual aid agreement.
But in the case of Helene, “effectively, the people who need help, their neighbors are also being affected. So, any given hospital, the closest hospitals to them, are likely dealing with the same issues,” Penta said. “That further complicates it, because things have to come from even farther away, whether that’s working within a network or ordering from different vendors.”
Over the weekend, North Carolina became the latest state to have a public health emergency declared by the U.S. Department of Health & Human Services (HHS) in response to Hurricane Helene.
The HHS’s Administration for Strategic Preparedness and Response deployed about 200 personnel to the state, including Health Care Situational Assessment teams to evaluate the storm’s impact on health care facilities such as hospitals, nursing homes and dialysis centers, and Disaster Medical Assistance teams to help state and local health workers provide care.
(NEW YORK) — The prevalence of obesity among adults has slightly decreased in the United States but remains higher than 10 years ago, new federal data shows.
Among adults aged 20 and older, about 40.3% were estimated to be obese between August 2021 and August 2023, according to a report released early Tuesday from the Centers for Disease Control and Prevention’s (CDC) National Center for Health Statistics.
This is lower than the 41.9% estimated to be obese between 2017 and 2020 but higher than the 37.7% figure recorded from 2013 to 2014.
Meanwhile, rates of severe obesity increased from 9.2% between 2017 and 2020 to 9.7% between August 2021 and August 2023. Between 2013 and 2014, an estimated 7.7% of adults were severely obese.
This means more than 100 million American adults have obesity, and more than 20 million adults have severe obesity, according to figures from the U.S. Census Bureau.
Dr. John Brownstein, an epidemiologist and chief innovation officer at Boston Children’s Hospital, and an ABC News contributor, said that although the data show a short-term slowdown of obesity rates, the prevalence is still quite high and higher than seen 10 years ago.
“The latest data reveals a persistent challenge with obesity rates holding steady at 40.3% among adults,” he said. “While this does not represent an increase, it is important to recognize that these rates are still alarmingly high — higher than they were a decade ago — underscoring the urgent need for targeted public health strategies.”
The prevalence of severe obesity was higher among women at 12.7% compared to 6.7% for men.
Among age groups, the prevalence of obesity was highest among adults between ages 40 and 59 at 46.4%. By comparison, the prevalence in adults between ages 20 and 39 was 35.5% and among those aged 60 and older was 38.9%. This pattern was seen in both men and women, according to the report.
Severe obesity prevalence was also highest among those aged 40 to 59 at 12% compared to 9.5% for those aged 20 to 29 and 6.6% for those aged 60 and older.
When it came to prevalence by education level, those with a bachelor’s degree or more had the lowest prevalence of obesity at 31.6% between August 2021 and August 2023.
There were no significant differences between men and women in obesity prevalence by education level, the report found.
Adults with obesity are at high risk of other chronic diseases. About 58% of obese adults in the U.S. have high blood pressure and about 23% have diabetes, according to the CDC.
Additionally, obesity can put a strain on the health care system. In 2019, the annual medical costs for adults with obesity were $1,861 higher per person than for adults with healthy weight. For those with severe obesity, excess costs were $3,097 per person, the CDC said.
“While there are some differences across demographics, this work really highlights that obesity is a broad health issue in the U.S. and that men, women, young and old are all affected,” Brownstein said. “Comprehensive approaches are essential to support individuals and communities in achieving healthier lifestyles.”
(NEW YORK) — Breast cancer deaths have fallen by 44% compared to 35 years ago, saving nearly 520,000 lives, according to a new report by the American Cancer Society.
The dramatic decrease is a major milestone in the fight against breast cancer, according to Dr. Lisa Newman, a co-author of the report, released on Tuesday, the start of Breast Cancer Awareness Month.
“This decline is evidence of our success in better treatments for breast cancer, especially with targeted treatments,” Newman, chief of the section of breast surgery at NewYork-Presbyterian/Weill Cornell Medical Center, told ABC News.
Beyond advances in care, Newman noted that mammography has also played a crucial role in detecting cancer earlier.
In April, the U.S. Preventive Services Task Force updated their guidelines, recommending that women at average risk for breast cancer get a mammogram every two years starting at age 40.
However, screening isn’t perfect, Newman stressed.
Women should watch for new lumps, skin changes, and nipple changes, including unusual discharge, pain, and redness.
Even if the last mammogram is clear, women should discuss any changes with a healthcare provider.
Steepest rise in new cases among women under 50
Though breast cancer deaths have dropped, new cases continue to rise.
From 2012 to 2021, breast cancer diagnoses increased by 1% each year, with the steepest rise among women under 50.
The reasons for the increase in diagnoses at a younger age remain unclear, Newman said.
“We speculate that it is related to differences in lifestyle and environment given the obesity epidemic and more women delaying their childbearing years and having fewer pregnancies over their lifetime,” she said.
Racial disparities in breast cancer persist
Yet despite lower overall death rates, racial disparities in breast cancer persist.
American Indian and Alaska Native (AIAN) women have seen no improvement in death rates, while Asian American/Pacific Islander (AAPI) women face the fastest uptick in new cases, with a nearly 3% annual increase.
And despite having 10% fewer cases than white women, AIAN women are 6% more likely to die from the disease and receive fewer regular mammograms.
Black women face a 38% higher chance of dying from breast cancer and have worse outcomes at every stage and subtype, except for localized cancers, compared to white women.
“Studies show that Black women are more likely to receive mammograms at lower-quality facilities, face delays in diagnosing abnormalities, and experience delays in starting and completing treatment,” Newman explained.
Because African American women are more prone to triple negative breast cancer, a particularly deadly form of the disease, Newman said there is a strong push to improve the diversity in clinical trials.
In May of 2024, the ACS launched the VOICES of Black Women Study which will enroll 100,000 Black women aged 25 to 55 and follow them for 30 years.
Newman also pointed out that breast cancer can affect men, especially African American men, who have double the risk compared to White men.
While the report revealed many promising trends in breast cancer, the disease remains the second most common cancer among women in the U.S. after skin cancer and the leading cause of cancer deaths for Black and Hispanic women. In 2024, experts predict over 300,000 new invasive (stage I and above) breast cancer cases with more than 40,000 deaths.
The report’s findings are based on data from the national cancer tracking programs that includes information from the National Cancer Institute and the Centers for Disease Control and Prevention.
(YEMASSEE, SC) — With four primates still on the loose after 43 of them escaped on Nov. 6 from the Alpha Genesis Inc. research laboratory in South Carolina, the Low Country facility has come under intense scrutiny.
Animal rights groups have cited the company’s history of violations and previous monkey breakouts; a member of Congress has called for an inquiry into its oversight by multiple federal agencies; and residents voiced concern the furry fugitives might spread disease throughout their community.
On top of it all, Alpha Genesis founder and CEO Gregory Westergaard told ABC News his company is investigating whether the release of the monkeys was “an intentional act” by an employee.
The quest for freedom by the pack of young female rhesus macaques coincides with the rapid expansion of the 100-acre Alpha Genesis facility and is casting light on a disruption in the U.S. medical research industry that sounds like a plot for a science fiction thriller. A 2023 report sponsored by the National Institutes of Health warned of a crisis involving the Chinese government that “undermines the security of the nation’s biomedical research enterprise.”
The case of the absconding primates has also raised questions about why the amount of federal contracts received by the testing and breeding operation has jumped more than 160% since 2021. According to USASpending.gov, a government website that tracks federal spending, the company has been granted $19 million in federal contracts this year alone.
“It’s shocking how much money is being spent on testing primates,” Rep. Nancy Mace, R-S.C., told ABC News.
Mace’s district encompasses the Beaufort County community of Yemassee, where the 6,701 primates housed at the sprawling Alpha Genesis facility nearly triple the number of town residents.
In a formal letter to the NIH, the agency that funds laboratory research, and the U.S. Department of Agriculture, which inspects and regulates breeding facilities, Mace expressed “very urgent concerns regarding federal oversight of Alpha Genesis.” Mace said the prolonged attempts to recapture all of the primates are “placing the animals and my constituents at risk.”
“A lot of constituents were concerned about whether or not the primates that escaped were sick or ill, or have been tested on,” Mace told ABC News. “There were a lot of folks concerned about the facility being a breeding facility and the testing that goes on there as well.”
The escape highlights an ‘issue of national security’
The incident some locals have referred to as “the great escape” has illuminated the international crisis hitting the animal research industry that Alpha Genesis’ Westergaard said has become “an issue of national security.”
In 2020, the Chinese government, the world’s primary breeder of research monkeys, banned the exports of nonhuman primates (NPH) to labs in the United States and elsewhere, triggering an international shortage of the animals just as research scientists were scrambling to come up with vaccines to combat the COVID-19 pandemic, according to a May 2023 report by National Academy of Engineering and National Academy of Medicine.
Primates, according to the NIH-supported report, are valuable in answering certain research questions because of their genetic, anatomic, physiologic and behavioral similarities to humans. However, the China ban on exporting research animals exacerbated the shortage and stalled NIH-funded research, according to the report.
The report concluded that the United States “needs to prioritize expansion” of domestic primate breeding programs.
“Relying on importing these animals from other countries is unsustainable, and dependence on international sources undermines the security of the nation’s biomedical research enterprise,” the report warned.
In 2021, the National Primate Research Centers could not meet two-thirds of researcher requests for rhesus macaques, according to the report.
“Researchers also face increased wait times for animals, and costs have risen 10% to 200% for a single animal, depending on the species,” the report said.
What we know about Alpha Genesis’ research
The crisis prompted Alpha Genesis to increase its domestic breeding of research primates. According to Rep. Mace, the company also manages the NIH’s so-called “Monkey Island” on Morgan Island in Beaufort County, which holds another 3,300 primates.
Westergaard told ABC News that Alpha Genesis employs 275 people, plus 30 or so contractors.
In addition to breeding lab monkeys, Alpha Genesis provides researchers across the country with biological products and materials, including serum, plasma, whole blood and tissue samples from a wide variety of research species, according to the company’s website. The private company’s researchers have helped develop several therapeutic drugs and vaccines, including those to treat the COVID-19 virus.
According to NIH online records provided to USASpending.gov, the crisis appears to be in accord with a boost in federal contracts Alpha Genesis has received, jumping from $7.3 million in 2021 to $12.3 million in 2022, $14.2 million in 2023 and $19 million this year.
Primates are worth up to $30,000 each
“The price of research monkeys has indeed increased a great deal since the Chinese banned all exports,” Westergaard said in an email to ABC News. “Prior to the ban monkeys sold for around $4K – $6K, after the ban prices have increased to $10K – $30K+ due to increased costs of raising animals in the US compared to China. An important point to note is that the shortage remains severe and a great deal of research in the US simply cannot be done because animals are not available at any cost.”
Westergaard said some suppliers of laboratory primates have turned to the illegal sourcing of wild-caught monkeys from Cambodia, “which we have not done.”
“It should also be noted that the Chinese government is seeking worldwide domination in medical research and the development of bio-weapons to target US citizens and our allies,” Westergaard said.
He added, “Alpha Genesis is a leading provider of NHPs to the US market and has been instrumental in attempting to fill this void. The alternative is to allow the Chinese to dominate medical development to the severe detriment of our National Security interests.”
“It should also be noted that the Chinese government is seeking worldwide domination in medical research and the development of bio-weapons to target US citizens and our allies,” Westergaard said.
He added, “Alpha Genesis is a leading provider of NHPs to the US market and has been instrumental in attempting to fill this void. The alternative is to allow the Chinese to dominate medical development to the severe detriment of our National Security interests.”
Human error or intentional act?
Asked by ABC News whether the rapid expansion of Alpha Genesis’ breeding and testing operations might have played a role in the escape of the 43 primates, Westergaard said the cause of the escape remains under investigation, including whether it was the result of “human error” or an “intentional act.”
“All the information we have thus far indicates that this is human error due to an employee failing to secure containment doors behind her, and a third door directly containing the animals, while doing routine cleaning and feeding,” Westergaard said in an email. “The enclosure was brand new and in perfect working order. We continue to investigate in an attempt to determine to the greatest extent possible whether this was or was not an intentional act.”
Westergaard said that immediately after the incident occurred, the employee’s supervisor told her she could be fired if it was determined that no structural failure of the primates’ enclosure led to the incident. Westergaard said the employee walked off the job and has not returned.
As of early Tuesday, four of the escaped primates remained on the loose, Westergaard said. Two were caught Monday, he said.
“The girls from today are in good health and the others continue to thrive,” Westergaard said Monday. “We believe the four monkeys remaining are probably all together either in the area adjacent to our property or somewhere else very close by.”
Mace has requested answers from NIH Director Monica Bertagnolli, USDA Deputy Administrator for Animal Care Sarah Helming, and Acting Director Axel Wolf of the NIH’s Office of Laboratory Animal Welfare. She also noted that this was not the first time problems had arisen at the research lab.
Mace, who told ABC News she is against animal testing, cited in her letter a September 2022 USDA inspection report of Alpha Genesis that found six separate incidents of animals escaping from their primary enclosures between January and August of 2022. Mace also cited escapes dating back to 2014, when more than two dozen monkeys slipped out of the facility, resulting in a fine from the USDA.
The 2022 USDA inspection report, which ABC News reviewed, also found an infant monkey died after becoming entangled in a stretch of gauze material used in an enclosure to hold a water bottle; said two primates were found dead in their enclosures with their fingers entrapped in structures inside their cages; and documented that one animal died from trauma and four others required veterinary care after they were placed in incorrect enclosures and were attacked by other primates unfamiliar with them.
As a result of the inspection, Alpha Genesis, according to the report, took corrective action to secure enclosures and “made significant changes” to avoid putting primates in the wrong enclosures.
The latest USDA routine inspection of Alpha Genesis lab was conducted on May 21 and concluded, “No non-compliant items identified during this inspection,” according to USDA online records.
“This is also true of several other inspections in recent years,” Westergaard said. “For a facility of this size that is quite remarkable.”
Mace said she met with Westergaard last week to discuss the escape and what Alpha Genesis is doing to round up the monkeys.
“It was an interesting conversation,” Mace said. “He tried to tell me how good the primates have it at his facility. And my response was, they have it good until you kill them with disease.”
Asked about the conversation, Westergaard responded: “I spoke to the congresswoman last week and at that time she said that she recognized the economic importance of our company to the people of the Low Country and that as a locally-owned business, she would continue to offer her full support.”
Alternatives to testing primates
Angela Grimes, CEO of Born Free USA, an international wildlife conservation and animal protection organization, told ABC News that her group has sent a letter to Alpha Genesis offering to rehome the escaped primates to its animal sanctuary in South Texas, where more than 200 rhesus macaque monkeys now reside, including some rescued from U.S. research labs. She said an anonymous donor has pledged $250,000 to help move the animals to the sanctuary.
“What we’d like to see is these animals be released to the Born Free USA sanctuary in South Texas, where they can have some of that freedom that they’ve just gotten a taste of,” Grimes said.
Grimes said Alpha Genesis has not responded to her group’s offer.
The nonprofit Born Free USA Primate Sanctuary, a 175-acre facility in Dilley, Texas, has been accredited since 2009 by the Global Federation of Animal Sanctuaries, GFAS executive director Valerie Taylor told ABC News, adding that her group conducts rigorous assessments and inspections of animal sanctuaries across the United States and around the globe to ensure the highest standard of animal care possible. Taylor said U.S. animal sanctuaries undergo accreditation every three years and that her organization recently visited the Born Free USA sanctuary as part of the reaccreditation process.
“We meet and exceed GFAS’ highest standards,” Grimes said.
Grimes said the medical research industry needs to research alternatives to subjecting primates to experimental testing of deadly diseases.
“I understand human health is important, but I also look at the other viable alternatives that are out there that do not result in the suffering and death of animals,” Grimes said.
Westergaard said testing of primates is necessary, though.
“There is no safe or effective way to make the leap from simpler model organisms like mice and rats to humans without using NHPs as an intermediary,” Westergaard said. “The therapeutics created using NHPs as research models directly lead to lifesaving and life-prolonging treatments and cures for human disease. Without NHPs as a research model, the world would still be ravaged with wide-spread polio, smallpox wouldn’t be eradicated, and HIV would still be a death sentence.”
