Health

Trump administration announces deal to lower weight loss drug prices for many Americans

Andrew Harnik/Getty Images

(WASHINGTON) — The Trump administration announced deals on Thursday with pharmaceutical giants Novo Nordisk and Eli Lilly that would lower the cost of GLP-1 drugs for many Americans, including those on Medicare.

The administration negotiated how much both the government and consumers would pay for the drugs, which are used to treat obesity and diabetes as well as other cardiometabolic conditions.

As soon as the public-private partnership TrumpRx launches, patients using the service will pay roughly $350 for a month’s supply of the injectable drugs, according to senior administration officials.

That price is set to scale down to $250 over the next two years for people paying completely out-of-pocket with no insurance.

Those using the daily pill versions of the drug, which yet to be approved by the U.S. Food and Drug Administration, will have prices beginning at $150 for the starting doses, the senior administration officials said.

In comments from the Oval Office, President Donald Trump thanked the pharmaceutical companies and lauded the deal.

“This is a triumph for American patients that will save lives and improve the health of millions and millions of Americans,” he said.

Both companies are expected to come out with new GLP-1 pills that are set to be available starting sometime next year pending FDA approval.

The reported savings on what the government will be paying for the medications will help broaden the type of people eligible for the drug.

Those with severe obesity will soon be able to access the drug under Medicare. Medicare patients will have a $50 co-pay for the drugs and could see the new pricing as soon as mid-2026. Medicaid pricing and timing will be dependent by state as they opt in.  

Currently, federal insurance programs cover Novo Nordisk’s Wegovy — one of the GLP-1s for people who are overweight and have heart disease — but there is no medication for obesity alone covered by Medicare.  

“Until now, neither of these two popular drugs have been covered by Medicare for weight loss and they’ve only rarely been covered by Medicaid,” Trump said. “They’ve often cost consumers more than $1,000 per month and some a lot more than that. Americans have been spending as much as 520% for Zepbound and 1,400% more for Wegovy than patients in Europe.”

Under this announcement, people who are severely obese — considered to be a body mass index over 35 — will also be covered for the medications for a $50 co-pay, but it doesn’t include broad coverage for all people who are overweight or obese like many private insurance plans cover.

GLP-1 drugs currently cost roughly $500 out-of-pocket for those without insurance.

During the Oval Office announcement, a guest fainted, causing the press conference to be temporarily paused.

In a statement, Karoline Leavitt said the person who fainted was a representative of one of the pharmaceutical companies, adding that the “White House Medical Unit quickly jumped into action, and the gentleman is okay.”

In a statement to ABC News, Novo Nordisk said the person who fainted was not one of their executives.

“CEO Mike Doustdar and EVP, US Operations, Dave Moore were the only two Novo Nordisk representatives in the Oval Office. We hope the gentleman who suffered a medical incident today is okay,” the statement read.

The deal is another of the Trump’s administration’s “most favored nations” agreements with pharmaceutical companies, a deal that comes after the president signed an executive order in May ordering his administration to pursue the deals to reduce the price of drugs for Americans.

“Today marks a pivotal moment in U.S. health care policy and a defining milestone for Lilly, made possible through collaboration with the Trump administration,” David A. Ricks, Eli Lilly’s chair and CEO, said in a statement. “As we expand access to obesity treatments for more Americans and advance one of the most innovative obesity pipelines, we remain focused on improving outcomes, strengthening the U.S. health care system, and contributing to the health of our nation for generations to come.”  

In a separate statement, Mike Doustdar, president and CEO of Novo Nordisk, said the deal will expand patient access and affordability.

“Unlike any other medicine in the GLP-1 class today, semaglutide is the only molecule whose respective FDA indications span obesity, type 2 diabetes, liver disease, kidney disease and cardiovascular risk,” the statement read. “Novo Nordisk has always worked to secure affordable access to our innovative medicines, and today’s announcement will bring semaglutide medicines to more American patients at a lower cost, Importantly, this also expands obesity medication access in Medicare, which will allow people living with obesity to access authentic Wegovy.”

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Health

Eli Lilly’s next generation weight loss drug shows promise, early trial results suggest

Cheng Xin/Getty Images

(NEW YORK) — Eli Lilly’s next generation of weight loss drugs appear to show promise, possibly leading to even faster weight loss and added health benefits, early trial results suggest.

The pharmaceutical company presented the results for its newer drug at the annual ObesityWeek conference on Thursday.

Known as amylin analogs, these drugs slow digestion and curb appetite, similar to the more well-known GLP-1 drugs, but act through a different hormone.

Amylin is a hormone that is co-secreted with insulin through the pancreas and helps regulate blood glucose levels, appetite and gastric emptying, which is the process of food moving from the stomach to the intestines.

These drugs can treat type 2 diabetes and obesity by imitating the body’s natural amylin.

While the effects are similar to Eli Lilly’s GLP-1 drugs, Mounjaro and Zepbound, some studies have suggested that amylin analogs may lead to a lower loss of lean muscle mess relative to fat mass.

Early trial results of Eli Lilly’s amylin analog, known as eloralintide, helped patients who were overweight or obese — with at least one pre-existing condition related to obesity and without type 2 diabetes — lose 9.5% to 20.1% of their body weight.

This was compared to patients who lost 0.4% when taking a placebo, according to the trial results, which were published in the medical journal The Lancet.

Patients who were treated with eloralintide also saw improvements in blood pressure, fat levels in the blood stream and markers of inflammation.

Eli Lilly said it will begin phase 3 clinical trials after the promising results, with the aim to enroll patients by the end of the year.

“Obesity is a complex condition, and no single treatment works for everyone. To truly address each patient’s needs, we need therapies with different mechanisms of action so that each person can receive the treatment that offers the best balance of effectiveness and tolerability for them,” Dr. Liana K. Billings, lead author of the study and director of clinical and genetics research in diabetes and cardiometabolic disease at Endeavor Health in Skokie, Illinois, said in a statement.

She added that the early trial results underscore “the potential of amylin receptor agonists to expand our therapeutic strategies and better serve individuals living with obesity.”

Eli Lilly is not the only drug company testing amylin analogs. Novo Nordisk’s version, called cagrilintide, led to about a 12% weight loss over 68 weeks in early, previously published studies.

Novo is testing a combination of cagrilintide and semaglutide — the latter of which is known under the brand name Wegovy — that produced about a 22% weight loss in people with obesity but not diabetesin a previously published, late-stage clinical trial. 

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Health

Some SNAP recipients say they have to choose between rent and food amid halt in benefits

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(NEW YORK) — Over the last week, Martina Santos said she feels like she’s been living a nightmare.

The 67-year-old from the Bronx, New York, is one of the nearly 42 million Americans who saw their Supplemental Nutrition Assistance Program (SNAP) benefits lapse on Nov. 1.

Although the U.S. Department of Agriculture said it would partially fund the program using emergency funds, officials said it could take “a few weeks to up to several months.” Additionally, President Donald Trump said on Tuesday that no benefits will be distributed until the government reopens.

The uncertainty of if or when SNAP benefits will be funded is leaving many Americans, like Santos, wondering whether she is going to pay rent, pay her bills or buy food.

“This is crazy. I’m nervous … thinking about how I can get the money to buy what I need right now, because I don’t have food stamps,” she told ABC News. “I need to make a decision if I pay my rent, when I pay my electricity or I buy food. It’s not easy.”

Santos, who volunteers at the nonprofit West Side Campaign Against Hunger, said she is asking her landlord if it’s possible to make a partial payment for the month of November.

She added that she’s going to a pantry this week because she doesn’t have much food in her house besides packets of beans and cereal, along with a gallon of milk her son bought for her.

In addition to food, Santos said the loss of benefits is particularly devastating because she uses them to purchase distilled water for her CPAP machine, which helps treat sleep apnea and, in turn, her high blood pressure.

“When I don’t use the machine, by the next day, I [wake] up tired, I don’t want to do anything, because I don’t sleep [well],” she said. “I want to wake up. How can I get out of this nightmare right now?”

Domestic violence survivors impacted by loss of SNAP benefits

Nicole, 42, from Long Island, New York — who asked that her last name not be used — started receiving SNAP benefits in 2024 after leaving a domestic violence situation.

She receives about $994 in SNAP benefits per month to help buy groceries for her and her three children — ages 12, 13 and 17 — which she said is a struggle.

“Food is so expensive right now. So, when you go into stores and you’re buying and trying to budget and save, it’s just not enough,” she told ABC News. “That’s the feeling that I get when I go food shopping. I’m a budget shopper. I try to look out for deals that they’re having and just stock up and be a bulk shopper.”

Nicole said she receives cash assistance and help from family, which has helped cover the cost of some groceries in the wake of SNAP benefits being halted, but added she has been occasionally checking her mobile app to see if the EBT card balance is still $0.

“I’ve been checking periodically just to see if it’s going to say that food stamps are going to be available. I just still have this little hope in praying that it will be there,” she said. “And I was thinking to myself today, like, ‘How long do you think it’s gonna go and thank God we’re getting the cash assistance and some people they just don’t have it. They just don’t have family.'”

She said she thinks this situation is going to last for a couple of months and said she is using this as motivation to hopefully get off of SNAP benefits for good.

Nicole Branca, CEO of New Destiny Housing, a nonprofit that provides housing to domestic violence survivors and their children, said 70% survivors that the organization serves receive SNAP benefits.

She said the loss of benefits can compound the physical and mental health struggles that many survivors already experience.

“Domestic violence survivors are particularly harmed by this loss of SNAP benefits because of the economic abuse that they’ve experienced,” she said. “Nearly 100% of DV survivors experience financial abuse as part of the abuse, so that means their abuser restricted their access to bank accounts, ruined their credit and didn’t allow them access to their own paycheck. And so we work with them to start from scratch.”

Branca continued, “It’s so hard to find the words to describe how devastating this is for our families, who are just starting to recover financially, emotionally, physically and the thought of not being able to pay for food on the table for their kids or having to decide between food and rent. It’s really taking a toll on our families.”

‘Anxious and concerned’

Elayne Masters, 68, from Pittsburgh, Pennsylvania, started receiving SNAP benefits in 2017 after suffering a traumatic brain injury following a fall down a flight of stairs.

In addition to her injury, Masters also suffers from hypothyroidism, which occurs when the thyroid gland doesn’t make and release enough thyroid hormone in the bloodstream, as well as Lyme disease, an inflammatory illness usually caused by an infected tick bite.

Masters typically receives about $250 in SNAP benefits, saying it allows her to buy healthy foods that help improve symptoms like brain fog, fatigue, confusion and joint pain.

She said her various conditions are improved by a healthy diet, and she’s worried that she won’t be able to buy nutrient-dense food without SNAP benefits.

“Foods that are basically high amounts of produce, vegetables and fruits, help to decrease the problematic health symptoms that I have and when I’m eating a really healthy diet, I’m doing better, I’m seeing the doctor less frequently, I’m taking fewer medications. I’m more functioning,” she told ABC News.

“And when I’m not able to pay for those healthy foods, my health declines, my cognitive functioning declines,” Masters went on. “If I weren’t able to maintain those healthy levels of eating, because it affects me so dramatically, so it’s a huge, huge difference in my quality of life and my ability to be a productive part of society as well.”

Masters said she went to a pantry last Wednesday and received a pre-packaged bag of food after attending a meeting at the Greater Pittsburgh Community Food Bank.

She said she is “anxious and concerned” about being able to pay her electric bill, car insurance and house insurance within the next month.

“Winter is coming, and heating bills will be higher. If anything breaks down, I’m in trouble,” she said. “The holidays are coming, and I may not be able to finish gift shopping.”

In the past, to make ends meet, Masters said she has done things to stretch the shelf life of her food, such as cutting mold off a block of cheese, peeling the rotting layers of an onion to reach the layers that are still good or saving vegetable scraps to make her own broth.

“I’m starting to consider, okay, what kinds of things can I do that are going to help me stretch my dollars and some of the strategies that I’ve used in the past?” Masters said. “I may be able to skate through a month, but much beyond that, and it’s going to be difficult.”

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Health

Debunking 8 claims about breast cancer screening: What every woman needs to know about detection

Pink ribbon flag in support of breast cancer awareness. Brent Lewis/The Denver Post via Getty Images

(NEW YORK) — When it comes to early detection, mammograms remain the only screening test proven to reduce deaths from breast cancer in average-risk women, according to the Centers for Disease Control and Prevention.

However, only about 75% of eligible U.S. women schedule regular screenings, according to a JAMA study published earlier this month.

Experts believe that misunderstandings about who needs screenings and how often may be part of the reason some women skip mammograms. Here are eight evidence-based facts about breast cancer screening to help set the record straight.

CLAIM: Only women with a family history need screening 

Although some women with family history of breast cancer may need earlier or more frequent screenings, all women need regular screenings, doctors said.

“Only about five to 10% of breast cancers are hereditary,” Dr. Aparajita Spencer, a breast surgical oncologist at CHI Memorial in Chattanooga, Tennessee, told ABC News. “Most women with breast cancer do not have a family history.”

CLAIM: A lump is the earliest sign of breast cancer

Although a lump is one of the most common symptoms of breast cancer, it is not the only sign and can be missed when performing self-examination.

“The whole point of the mammogram is to pick up the earliest signs of a breast cancer, which are usually calcifications, not really a mass,” Dr. Preeti Subhedar, breast surgery chief at Hackensack Hospital in New Jersey, told ABC News.

“When people come in with a mammographically or image-detected breast cancer, usually it’s fairly small and outcomes are really good,” she added.

CLAIM: Breast size affects your cancer risk

Subhedar said that breast size has nothing to do with risk.

“An average-risk woman has a 12% lifetime risk of developing breast cancer,” she said.

For high-risk women, this increases to over 20%, according to the American Cancer Society.

Spencer added that breast size and breast density are often confused, but they’re not the same. A mammogram will read dense breasts as having a higher proportion of glandular and fibrous tissue compared to fatty tissue. Mammary glands typically produce milk while fibrous tissue forms the breast.

This can slightly raise cancer risk and make tumors harder to catch, which is why the U.S. Food and Drug Administration finalized a rule in 2024 requiring providers to inform women if their breast tissue is dense and may require additional follow-up screenings.

CLAIM: Younger women don’t need mammograms

The National Comprehensive Cancer Network recommends annual screening mammograms starting at age 40 for average-risk women. 

For women with a strong family history of breast cancer or a known genetic mutation, the American Cancer Society recommends beginning annual screenings with both a mammogram and a breast MRI at age 30, or even earlier if a close relative was diagnosed at a young age.

CLAIM: A negative mammogram means you don’t have breast cancer

Experts said a mammogram does not mean a patient doesn’t have breast cancer but rather that breast cancer wasn’t found on that specific mammogram. 

“Mammograms occasionally miss early-stage cancers,” noted Spencer. “There is always a chance that you have something that pops up between screenings. We can’t say 100%, which is why it’s really important to get those yearly screenings.” 

CLAIM: Mammograms can cause cancer because of radiation

The benefit of early detection far outweighs the tiny risk from the small amount of radiation, experts said.

The total lifetime risk for radiation-induced breast cancer is still very low at one in 5,000 — compared to about one in every eight women who will develop breast cancer in their lifetime, and roughly one in 43 women who will die from it. 

CLAIM: There are safe and effective alternatives to mammograms

“There’s no universal replacement for screening mammograms. That is why that is the gold standard,” Spencer said. 

Mammograms are safe — even during pregnancy when needed, she added. Other diagnostic tools including, an MRI and an ultrasound, may be used to provide additional information, but they do not replace the mammogram. 

CLAIM: A breast biopsy spreads breast cancer

Medical experts agree that breast biopsies are safe, and the benefit of getting an accurate diagnosis far outweighs the minimal risks.

“It is extremely, extremely important that we get a tissue biopsy when someone comes in with an abnormal mammogram because there’s a lot of biological information that we learn about a tumor from that biopsy,” Spencer said. 

Breast cancer is the most common cancer in women after skin cancer and the second leading cause of cancer death, according to the American Cancer Society.

In 2024, more than 300,000 women were diagnosed with breast cancer, and about 40,000 died from the disease. Today, more than 3 million breast cancer survivors live in the U.S. —  a powerful reminder of the importance of early detection, doctors said.

Allyson Heng, MD, is resident physician in neurology at the University of Alabama at Birmingham and a member of the ABC News Medical Unit.

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Health

Head Start programs serving nearly 65,000 kids at risk of closing amid government shutdown

Lourdes Balduque/Getty Images

(NEW YORK) — Tens of thousands of children and families could be affected by dozens of Head Start programs potentially closing if the federal government shutdown extends past Nov. 1.

About 134 programs across 41 states and Puerto Rico will see their operational funding cease on Saturday, affecting nearly 65,000 kids, or 10% of all Head Start children, according to the National Head Start Association (NHSA).

Florida, Georgia, Missouri and Ohio may see the most impacts, potentially affecting more than 24,000 children and more than 7,500 staff members, NHSA data shows.

Head Start is a federal program run by the U.S. Department of Health and Human Services that provides early childhood education, health, nutrition and family support services to low-income children and families.

Programs shutting down could mean that children under age 6 could lose access to preschool education, health services and referrals. Families could lose access to affordable childcare that allows parents to work, attend school or undergo job training.

“We are concerned that the longer a government shutdown runs, the more likely it is that Head Start programs might be faced with potential closures and having deep impacts on children and families that we serve,” Tommy Sheridan, deputy director of NHSA, told ABC News. “The longer the shutdown goes, the more that number will increase and, at the end of the day, children and families should never be put at risk because of political gridlock. However, that’s exactly what’s happening right now.”

Programs struggle to find funding
Sheridan said not all of the 134 programs affected will close in November. Some are reaching out to state and local leaders and some are asking private organizations for funding, which may cover costs for a short period of time.

He said there are 1,600 programs across the U.S. so, while a majority of Head Start programs will not be affected after Nov. 1, it is still a substantial number that will either be struggling to remain open or may have to close.

An HHS spokesperson told ABC News that Democrats are to blame for the government shutdown and that, when the shuthown is over, the HHS’ Office of Head Start will work to expedite grant awards.

Central Kentucky Community Action Council Head Start and Early Head Start (CKCAC), which serves 400 children in nine centers across six counties, will lose access to an $8 million federal grant on Nov. 1, Bryan Conover, executive director of CKCAC, told ABC News.

Although CKCAC’s Head Start policy council affirmed unanimously to allow the group to pursue a line of credit for about $1 million with a local bank, it will only allow operations to be maintained until Nov. 21.

“All 400 of those families could be put in a situation where, if we have to close our doors, they’re going to choose whether or not to take care of their kids or work,” Conover said. “And so there really is multiple ripples of pain that ceasing operations would cause, and we’re hoping beyond hope that this shutdown ends very soon, that we don’t have to go through those painful conversations.”

Conover said if the shutdown extends past Nov. 21, “it’s going to make for some very unfortunate Thanksgiving situations.”

“If we get to Nov. 22 and we don’t have funding available, and we have to close our doors and SNAP may not be in place yet, we’re going to have vulnerable families missing out on nutrition for their kids, let alone education, let alone therapy, let alone the other supports they need to be able to be kindergarten-ready and let alone the impacts on the families who are going to have to make choices to potentially work or stay home to provide child care,” he continued.

The Ohio Head Start Association said seven providers serving more than 3,700 kids are at risk of closing because their federal funds will be exhausted on Nov. 1. The association said closures could force 940 staff members out of work.

“Every day the shutdown continues, Ohio children and families are paying the price,” said Julie Stone, executive director of the OHSA said in a statement. “Head Start is not a political issue — it’s a lifeline. Congress must act now to restore funding, keep classrooms open, and protect the stability of families, the staff who serve them, and communities.”

Closures could affect childhood development
Dr. Lindsey Burghardt, chief science officer at the Center on the Developing Child at Harvard University, said there could be negative effects on development from Head Start programs ending so suddenly.

She said these services help support children’s healthy physical and mental development through education, nutrition, having consistently available and responsible caregivers and having safe and clean places to play and learn.

Head Start programs may be the only way by which children receive nutritious meals, get health screenings or receive early intervention for developmental delays and special education.

“When you disrupt it, especially when you destabilize these services suddenly, I think you have the potential to disrupt healthy brain development, to derail the healthy development of all these other organ systems,” Burghardt told ABC News.

“And that’s important, because it can disrupt mental and physical health in childhood, but actually, really importantly, can disrupt health and well-being across those children’s life spans and have really long-lasting developmental implications,” she added.

Burghardt said the longer or larger disruption to these services, the more potential to negatively impact a child that could span throughout adolescence and decades later, when they’re an adult.

This can include poor academic and cognitive function as well as greater behavioral problems, Burghardt said.

The NHSA said research has shown Head Start programs have short-term and long-term impact, including less chronic absenteeism in middle school, improved high school graduation rates, increased higher education enrollment and completion and a decreased reliance on public assistance.

Sheridan said families, including parents and caregivers, may also feel negative impacts from Head Start programs shutting down.

“Families that are eligible for Head Start often work multiple jobs,” he said. “They might be in college or community college or a technical college or are in job training programs. …  So the families that are in Head Start, they’re doing everything that they can to try to better their situation and their child’s situation. They count on Head Start to be there so that they can navigate whatever they need to in order to be able to provide for their families.”

Sheridan went on, “Without Head Start, many parents will have no affordable child care option. They may be forced to leave their jobs. They may … reduce the hours that they might be working, not attend class, different things like that, horrible decisions that families do not want to have to make … and it’s going to be incredibly destabilizing and challenging.”

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Health

Texas AG sues makers of Tylenol over hiding alleged links to autism

Tylenol caplets are displayed on September 22, 2025 in San Anselmo, California. The Trump administration will reportedly link use of the painkiller acetaminophen during pregnancy to autism during a White House press conference today. (Photo Illustration by Justin Sullivan/Getty Images)

(NEW YORK) — Texas Attorney General Ken Paxton sued the makers of Tylenol, Johnson & Johnson and Kenvue, claiming that they deceptively marketed the over-the-counter medication to pregnant women despite alleged links to autism and other disorders.

“Big Pharma betrayed America by profiting off of pain and pushing pills regardless of the risks,” Paxton said in a statement on Tuesday. “These corporations lied for decades, knowingly endangering millions to line their pockets. … By holding Big Pharma accountable for poisoning our people, we will help Make America Healthy Again.”

This is the first lawsuit from a state government since President Donald Trump claimed last month that Tylenol use during pregnancy is linked to an increased risk of autism, despite limited evidence to suggest an association.

Johnson & Johnson sold the drug for decades and its consumer health division spinoff, Kenvue Inc., has been selling the drug since 2023.

In a statement, Kenvue pushed back on the attorney general’s claims, saying it is “deeply concerned by the perpetuation of misinformation on the safety of acetaminophen and the potential impact that could have on the health of American women and children.”

“Acetaminophen is the safest pain reliever option for pregnant women as needed throughout their entire pregnancy. Without it, women face dangerous choices: suffer through conditions like fever that are potentially harmful to both mom and baby or use riskier alternatives. High fevers and pain are widely recognized as potential risks to a pregnancy if left untreated,” the statement read. “We will defend ourselves against these baseless claims and respond per the legal process. We stand firmly with the global medical community that acknowledges the safety of acetaminophen and believe we will continue to be successful in litigation as these claims lack legal merit and scientific support.”

This is a developing story. Please check back for updates.

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Health

Women reach heart health goals with less exercise than men, new study suggests

A woman runs along a palm tree-lined street in La Jolla as the sun sets on the horizon of the Pacific Ocean on October 23, 2025 in San Diego, California. Kevin Carter/Getty Images

(NEW YORK) — Women may need less exercise than men to gain similar protection against coronary heart disease, according to a new study published in Nature Cardiovascular Research.

The findings come from an observational study of more than 85,000 adults in the United Kingdom who were followed for about seven years. Researchers used data from a one-time “snapshot” — a weeklong period of wrist-worn fitness tracker measurements — to examine how physical activity relates to heart disease risk and death rates.

The study found that women who got around four hours of moderate exercise each week lowered their risk of coronary heart disease by about 30%. However, men needed nearly twice as much — about eight hours of similar activity — to achieve the same level of heart protection. Additionally, women who already had heart disease experienced a threefold decrease in the risk of death compared with men with similar medical histories, who needed nearly twice as much weekly exercise to achieve a similar reduction in the risk of dying from any cause.

Moderate-intensity exercise includes activities like brisk walking or gardening — enough to get the heart pumping but not to the point of exhaustion, according to Dr. Jennifer Miao, a board-certified cardiologist and fellow of the ABC News Medical Unit. More vigorous workouts such as running, swimming laps or hiking uphill push the body harder and lead to a greater rise in heart rate, she explained.

The American Heart Association recommends that adults get at least two-and-a-half hours per week of moderate-intensity physical activity, or one-and-a-half hours per week of vigorous activity, or a combination of both. But even when following those exercise recommendations, the study found that differences between the sexes emerged.

Across all groups, the study confirmed that being active at any level was associated with a lower risk of heart disease compared with leading a sedentary lifestyle, with active women experiencing a 5% greater reduction in risk than active men.

And the more exercise someone got, the lower their risk of heart disease and death, highlighting what experts refer to as a clear dose-response relationship between physical activity and heart health.

There are two possible reasons women may benefit more from physical activity than men, according to the study authors. One explanation could be hormones.

“Physiologically, circulating estrogen levels are much higher in females than in males, and estrogen can promote body fat loss during exercise,” Dr. Jiajin Chen, one of the study’s authors and a researcher at the Institute of Cardiovascular Diseases in China, told ABC News.

Another possible reason has to do with muscle type. Men tend to have more “fast-twitch” muscles, which are great for quick, powerful movements. Women, on the other hand, usually have more “slow-twitch” muscles, which may help their bodies work a bit more efficiently during workouts.

“These physiological differences may partly explain the increased sensitivity to physical activity and greater cardiovascular benefit observed in females,” Chen said.

It’s also important to recognize how men and women can experience and be treated for coronary artery disease differently, Miao noted.

Women often develop the condition later in life, face a higher risk of death following a heart attack, and are less likely than men to undergo diagnostic procedures such as coronary angiography or receive standard medical care for coronary artery disease, she said.

Public health guidelines will benefit from acknowledging these sex-based differences to more effectively prevent cardiovascular disease, which is the world’s leading cause of death, the study authors suggest.

Miao agreed. She advised talking with your doctor before starting a new exercise routine, since physical activity recommendations depend on your fitness level, medical conditions, recent events like a stroke or heart attack, and overall mobility.

“Exercise routines should be personalized; it’s not a one-size-fits-all plan,” Miao said.

Dr. Cyrus Mowdawalla, MD, is a resident physician in internal medicine from Montefiore Medical Center and a contributing correspondent of the ABC News Medical Unit.

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Health

Some Americans fear high premiums if ACA enhanced subsidies expire: ‘It’s very much a worry’

House Speaker Mike Johnson (R-LA) speaks at a press conference with other House Republicans on the 15th day of the government shutdown in Washington, DC on October 15, 2025. Nathan Posner/Anadolu via Getty Images

(NEW YORK) — As the federal government shutdown enters its third week, some Americans are worried about the future of the Affordable Care Act (ACA) subsidies.

The subsidies, or premium tax credits, help lower or eliminate the out-of-pocket cost of monthly premiums for those who purchase insurance through the health insurance marketplace.

They were enhanced during the COVID-19 pandemic and are currently set to expire at the end of 2025.

Democrats have been demanding that Republicans pass extensions of the subsidies before the government is reopened, while the GOP says it won’t negotiate until a clean funding bill passes and the government reopens.

A recent analysis from KFF found that premium payments could more than double in 2026 if the ACA enhanced premium tax credits expire.

Some Americans who rely on the tax credits to help pay for some or all of their or their family’s premiums told ABC News they’re worried that if the subsidies expire, they may be forced to choose a less comprehensive insurance plan or they may not be able to cover the cost of their premiums.

We ‘can’t afford to not have insurance’

Doug Butchart, 67, from Eglin, Illinois, told ABC News that his wife, Shadene, has amyotrophic lateral sclerosis (ALS), and currently receives her insurance through the health insurance marketplace.

Shadene Butchart, 58, started off on a Blue Cross bronze plan — or the lowest tier — but, as her disease progressed, the couple decided to upgrade to a gold plan, the highest tier, which covers a higher percentage of her health care costs.

The premium under this plan is $1,273.82 per month. The Butcharts receive enhanced premium tax credits that cover $670 of the monthly premium, leaving them to pay $603.82 per month themselves.

Without the premium tax credits, Doug Butchart said they cannot afford to pay the entire premium out of pocket each month.

“I’ve heard [premiums could rise] anywhere from 25 to 50%,” he said. “And that’s not sustainable because we can’t afford that but can’t afford to not have insurance.”

Doug Butchart said his wife doesn’t quality for Medicare and they don’t meet the income threshold to qualify for Medicaid.

“We’re stuck like in the middle because, normally with an ALS diagnosis, you’re automatically eligible for [Social Security Disability Insurance] and Medicare, but she doesn’t have any work credits, so she doesn’t qualify for Social Security Disability,” he explained. “So right now, we’re doing everything off of my Social Security, and it’s very hard to try and pay all the bills and keep insurance and, if they mess around with the marketplace insurance, it’s going to make it impossible for us to afford insurance.”

Now that the Butcharts have met the deductible for the year, combined with the anticipation of possibly losing tax credits and going to a lower tier insurance plan, the couple is trying to use insurance to get as much equipment as Shadene Butchart needs to manage her ALS before the end of the year.

This includes an order for a new wheelchair that Shadene Butchart could drive with her eyes, and that could cost anywhere from $65,000 to $95,000, Doug Butchart said.

Doug Butchart said they may have to downgrade to a lower-tier plan next year, but he’s not sure if the medications his wife currently takes will be covered by a “lesser plan.”

Doug Butchart, who is a retired mechanic, said he feels lucky that he does not need to worry about house or car payments — both of which are paid off — but there are other bills to pay and he did not expect to have to struggle to meet insurance costs every month.

“You work your entire life to make yourself comfortable and I’m sure there are things that we could do without but there’s not that much crazy spending to possibly have to cover $1,500 a month for insurance,” he said. “That’s a lot of money. … You don’t realize how important insurance is until you need it.”

‘It’s very much a worry’

Nancy Murphy, a retired registered nurse and insurance industry employee, was able to receive insurance through the ACA for the first time this year with Florida Blue.

Every month, her premium is $1,019 and the enhanced premium tax credits cover the total cost, she told ABC News. If there is no deal made before the Nov. 1 open enrollment deadline or the tax credits expire at the end of the year, she’s concerned about being able to cover the cost.

“It’s very much a worry. I definitely could not afford that if the tax credits expire,” said Murphy, 60, who lives in Fort Lauderdale. “It’s a scary thought as a type 1 diabetic.”

Murphy said she uses an insulin pump to manage her diabetes, which is covered by her insurance without a co-pay. However, she said she sometimes uses other medications that have a $30 a month co-pay.

She added that losing the tax credits is a concern because she has other costs she wants to make sure she can manage including property taxes and her daughter’s tuition for college in Boston.

Without knowing exactly how much premiums are going to increase by, she said she’s very anxious about what her budget will look like.

“I’m like in limbo and it’s a really uncomfortable feeling,” Murphy said. “I like to budget and plan out my budget. With tuition, property taxes and repairs that need to be done around the house, I need to map these out.”

She continued, “These things to me are so upsetting. We are American citizens. We should be able to access our tax dollars for our heath care needs.”

Copyright © 2025, ABC Audio. All rights reserved.

Health

California officials investigate possible local spread of mpox after 3 cases with no travel history reported

NIH-NIAID/Image Point FR/BSIP/Universal Images Group via Getty Images

(NEW YORK) — Health officials in Los Angeles County said on Friday they are investigating a possible local spread of a more severe strain of mpox.

Two cases of the strain were identified among Los Angeles County residents with no recent travel history.

It comes after the first U.S. case of the more severe strain of mpox without known travel was identified in a patient from Long Beach, California, bringing the total number of cases in the state to three.

No clear link has been identified between the Los Angeles cases and the Long Beach case, according to Los Angeles County health officials.

“The confirmation of a third case with no travel history raises concerns about possible local spread in Los Angeles County,” Dr. Muntu Davis, Los Angeles County health officer, said in a press release. “We’re working closely with our partners to identify potential sources and understand how this potentially more serious type of the mpox virus may be spreading.”

There are two types of the virus that cause mpox: clade I and clade II, with clade roughly meaning they are descended from a common ancestor organism. Clade I has historically been associated with severe illness and death, and is endemic to parts of central and western Africa, according to the Centers for Disease Control and Prevention (CDC).

Clade II was responsible for a large outbreak that peaked in summer 2022, leading to more than 100,000 cases in 122 countries, including more than 30,000 cases in the U.S.

The less severe strain in the U.S. has continued circulating at low levels and has remained relatively stable.

Parts of Africa have been dealing with sustained person-to-person spread of the more severe strain of mpox. All six previously confirmed cases of the more severe strain in the U.S. have been among people who had recently traveled to areas associated with the outbreak in central and eastern Africa, according to the CDC.

In November 2024, California reported the first domestic case of the more severe strain in a traveler from Africa who experienced mild illness.

People with mpox, which was formerly known as monkeypox, often get a rash that can be located on hands, feet, chest, face, mouth or near the genitals, the CDC said.

Most people with mpox typically recover within two to four weeks without specific treatments.

Currently, the JYNNEOS vaccine, a two-dose vaccine approved by the Food and Drug Administration to prevent smallpox and mpox, is the only vaccine being used in the U.S.

The JYNNEOS vaccine is  recommended for adults at high risk for mpox, which includes people who are gay, bisexual or other men who have sex with men and have recent or upcoming risk factors like multiple sexual partners, intimate contact with someone who may have mpox, or sex at commercial venues.

ABC News’ Mary Kekatos contributed to this report.

Copyright © 2025, ABC Audio. All rights reserved.

Health

California officials confirm 1st US case of severe mpox strain with no travel history

NIH-NIAID/Image Point FR/BSIP/Universal Images Group via Getty Images

(NEW YORK) — The first U.S. case of a more severe strain of mpox without any recent travel history has been identified in California.

Health officials said this week that the case was confirmed in a Long Beach resident. The patient required hospitalization and is now isolating and recovering at home.

No other identifying details were provided about the patient, including name, age or sex.

While this is the seventh case of the more severe strain confirmed in the U.S this year, it is the first without known travel, according to local officials.

Officials say the risk to the general public is low and the health department is conducting an investigation, including working to identify the patient’s potential sources of exposure.

“We are taking this very seriously and ensuring our community and health care partners remain vigilant so we can prevent any more cases,” Long Beach Mayor Rex Richardson said in a press release. “This underscores the importance of continued surveillance, early response and vaccination.”

There are two types of the virus that cause mpox: clade I and clade II, with clade roughly meaning they are descended from a common ancestor organism. Clade I has historically been associated with severe illness and death, and is endemic to parts of central and western Africa, according to the Centers for Disease Control and Prevention (CDC).

Clade II was responsible for a large outbreak that peaked in summer 2022, leading to more than 100,000 cases in 122 countries, including more than 30,000 cases in the U.S.

The less severe strain in the U.S. has continued circulating at low levels and has remained relatively stable.

Parts of Africa have been dealing with sustained person-to-person spread of the more severe strain of mpox. All six previously confirmed cases of the more severe strain in the U.S. have been among people who had recently traveled to areas associated with the outbreak in central and eastern Africa, according to the CDC.

In November 2024, California reported the first domestic case of the more severe strain in a traveler from Africa who experienced mild illness.

People with mpox, which was formerly known as monkeypox, often get a rash that can be located on hands, feet, chest, face, mouth or near the genitals, the CDC said.

Most people with mpox typically recover within two to four weeks without specific treatments.

Currently, the JYNNEOS vaccine, a two-dose vaccine approved by the Food and Drug Administration to prevent smallpox and mpox, is the only vaccine being used in the U.S.

The JYNNEOS vaccine is  recommended for adults at high risk for mpox, which includes people who are gay, bisexual or other men who have sex with men and have recent or upcoming risk factors like multiple sexual partners, intimate contact with someone who may have mpox, or sex at commercial venues.

ABC News’ Mary Kekatos contributed to this report.

Copyright © 2025, ABC Audio. All rights reserved.