Bird flu case reported in Los Angeles after state officials declare emergency
CDC and NIAID
Los Angeles County health officials reported the first human case of bird flu in the area less than a week after a statewide emergency declaration was announced.
In a statement released on Monday, the L.A. County Department of Public Health said the human case of H5 bird flu was detected in an adult who was exposed to livestock infected with the virus at a worksite.
The unnamed adult had mild symptoms, has been treated with antivirals and is recovering at home, according to the agency.
“The overall risk of H5 bird flu to the public remains low,” health officials said.
There are at least 65 confirmed human cases of bird flu nationally — with at least 36 in California, according to the CDC.
California Gov. Gavin Newsom declared a state of emergency on Dec. 18 as bird flu cases were detected in dairy cows on Southern California farms. The virus had also been previously detected in the state’s Central Valley.
“This proclamation is a targeted action to ensure government agencies have the resources and flexibility they need to respond quickly to this outbreak,” Newsom said in a statement last week.
Symptoms of bird flu in humans include eye redness or discharge, fever, cough or difficulty breathing, sore throat, muscle or body aches, diarrhea and vomiting, according to health officials.
Individuals working with infected animals, including cows, poultry or wildlife, continue to be at higher risk of exposure to the virus.
“People rarely get bird flu, but those who interact with infected livestock or wildlife have a greater risk of infection. This case reminds us to take basic precautions to prevent being exposed,” Los Angeles County health officer Muntu Davis, MD, MPH, said in the statement Monday.
“People should avoid unprotected contact with sick or dead animals including cows, poultry, and wild birds; avoid consuming raw or undercooked animal products, such as raw milk; and protect pets and backyard poultry from exposure to wild animals,” Davis added.
The health official also recommended getting the seasonal flu vaccine “which can help prevent severe seasonal flu illness and lower the risk of getting both seasonal and bird flu infections at the same time if exposed.”
(VANCOUVER ISLAND, CANADA) — Police in Canada said they have arrested six people and taken down an organized crime group believed to have produced tens of thousands of counterfeit cannabis-laced candy bars and edibles resembling popular name-brand products.
The takedown began early this month when the Pacific Region Royal Canadian Mounted Police federal policing investigators executed search warrants at two dispensaries and five separate residences on Vancouver Island in British Columbia, Canada, on Oct. 3, according to a statement from the Royal Canadian Mounted Police on Tuesday.
“These warrants were associated to an organized crime group allegedly involved in the production and distribution of illicit drugs, and contraband tobacco in Port Alberni and Nanaimo,” authorities said. “The dispensaries in question were Green Coast Dispensary in Port Alberni and Coastal Storm Dispensary located in Lantzville.”
Search warrants were also executed at a suspected stash site in Port Alberni, as well as a storage and production facility adjacent to Coastal Storm Dispensary, including two modular trailers where cannabis edibles were being produced, stored, and distributed, authorities said.
The list of items seized includes over 120,000 cannabis edibles with packaging resembling popular name-brand chocolate bars, potato chips, nacho chips, honey and other candies, including over 3 kilograms (6.6 pounds) of psilocybin mushrooms, 1,740 psilocybin capsules, over 400 psilocybin chocolate, candies and a multitude of other psilocybin products, 2.2 pounds of pressed cannabis resin, over 500 pounds of cannabis bud, more than 19 pounds of shatter, over 5000 cannabis vape cartridges, counterfeit cannabis-laced honey, five vehicles, two ATM machines containing cash, an estimated 164 master cases of contraband tobacco equating to 82,000 packs of cigarettes, over $400,000 in cash and a shotgun, police said.
“Although the contraband cannabis-laced candy bars and chips resembled professionally manufactured, packaged, and quality-controlled products, they were discovered to have been produced in the highly unsanitary, and heavily contaminated modular trailers,” authorities from RCMP said. “A preliminary assessment of the edibles also indicates that they had been treated with unknown amounts of THC, and likely cross-contaminated with other drugs and substances present in the trailers where they were being produced and packaged.”
Of equal concern, according to police, was the fact that the counterfeit snacks had packaging claims of possessing medicinal properties and dangerously high drug potency values, with many of the candy wrap labels claiming to be “100 times more potent than regulated cannabis products.”
“Given the highly contaminated and unsanitary conditions of the illicit drug production facility where these cannabis edibles were being produced, it is possible that the consumption of these products can lead to serious health risks,” RCMP said. “We urge members of the public to practice extreme caution if they already possess, or come across such products in the future, especially with Halloween being just around the corner.”
This investigation is ongoing and numerous drug-offence-related charges are being pursued.
(YEMASSEE, SC) — With four primates still on the loose after 43 of them escaped on Nov. 6 from the Alpha Genesis Inc. research laboratory in South Carolina, the Low Country facility has come under intense scrutiny.
Animal rights groups have cited the company’s history of violations and previous monkey breakouts; a member of Congress has called for an inquiry into its oversight by multiple federal agencies; and residents voiced concern the furry fugitives might spread disease throughout their community.
On top of it all, Alpha Genesis founder and CEO Gregory Westergaard told ABC News his company is investigating whether the release of the monkeys was “an intentional act” by an employee.
The quest for freedom by the pack of young female rhesus macaques coincides with the rapid expansion of the 100-acre Alpha Genesis facility and is casting light on a disruption in the U.S. medical research industry that sounds like a plot for a science fiction thriller. A 2023 report sponsored by the National Institutes of Health warned of a crisis involving the Chinese government that “undermines the security of the nation’s biomedical research enterprise.”
The case of the absconding primates has also raised questions about why the amount of federal contracts received by the testing and breeding operation has jumped more than 160% since 2021. According to USASpending.gov, a government website that tracks federal spending, the company has been granted $19 million in federal contracts this year alone.
“It’s shocking how much money is being spent on testing primates,” Rep. Nancy Mace, R-S.C., told ABC News.
Mace’s district encompasses the Beaufort County community of Yemassee, where the 6,701 primates housed at the sprawling Alpha Genesis facility nearly triple the number of town residents.
In a formal letter to the NIH, the agency that funds laboratory research, and the U.S. Department of Agriculture, which inspects and regulates breeding facilities, Mace expressed “very urgent concerns regarding federal oversight of Alpha Genesis.” Mace said the prolonged attempts to recapture all of the primates are “placing the animals and my constituents at risk.”
“A lot of constituents were concerned about whether or not the primates that escaped were sick or ill, or have been tested on,” Mace told ABC News. “There were a lot of folks concerned about the facility being a breeding facility and the testing that goes on there as well.”
The escape highlights an ‘issue of national security’
The incident some locals have referred to as “the great escape” has illuminated the international crisis hitting the animal research industry that Alpha Genesis’ Westergaard said has become “an issue of national security.”
In 2020, the Chinese government, the world’s primary breeder of research monkeys, banned the exports of nonhuman primates (NPH) to labs in the United States and elsewhere, triggering an international shortage of the animals just as research scientists were scrambling to come up with vaccines to combat the COVID-19 pandemic, according to a May 2023 report by National Academy of Engineering and National Academy of Medicine.
Primates, according to the NIH-supported report, are valuable in answering certain research questions because of their genetic, anatomic, physiologic and behavioral similarities to humans. However, the China ban on exporting research animals exacerbated the shortage and stalled NIH-funded research, according to the report.
The report concluded that the United States “needs to prioritize expansion” of domestic primate breeding programs.
“Relying on importing these animals from other countries is unsustainable, and dependence on international sources undermines the security of the nation’s biomedical research enterprise,” the report warned.
In 2021, the National Primate Research Centers could not meet two-thirds of researcher requests for rhesus macaques, according to the report.
“Researchers also face increased wait times for animals, and costs have risen 10% to 200% for a single animal, depending on the species,” the report said.
What we know about Alpha Genesis’ research
The crisis prompted Alpha Genesis to increase its domestic breeding of research primates. According to Rep. Mace, the company also manages the NIH’s so-called “Monkey Island” on Morgan Island in Beaufort County, which holds another 3,300 primates.
Westergaard told ABC News that Alpha Genesis employs 275 people, plus 30 or so contractors.
In addition to breeding lab monkeys, Alpha Genesis provides researchers across the country with biological products and materials, including serum, plasma, whole blood and tissue samples from a wide variety of research species, according to the company’s website. The private company’s researchers have helped develop several therapeutic drugs and vaccines, including those to treat the COVID-19 virus.
According to NIH online records provided to USASpending.gov, the crisis appears to be in accord with a boost in federal contracts Alpha Genesis has received, jumping from $7.3 million in 2021 to $12.3 million in 2022, $14.2 million in 2023 and $19 million this year.
Primates are worth up to $30,000 each
“The price of research monkeys has indeed increased a great deal since the Chinese banned all exports,” Westergaard said in an email to ABC News. “Prior to the ban monkeys sold for around $4K – $6K, after the ban prices have increased to $10K – $30K+ due to increased costs of raising animals in the US compared to China. An important point to note is that the shortage remains severe and a great deal of research in the US simply cannot be done because animals are not available at any cost.”
Westergaard said some suppliers of laboratory primates have turned to the illegal sourcing of wild-caught monkeys from Cambodia, “which we have not done.”
“It should also be noted that the Chinese government is seeking worldwide domination in medical research and the development of bio-weapons to target US citizens and our allies,” Westergaard said.
He added, “Alpha Genesis is a leading provider of NHPs to the US market and has been instrumental in attempting to fill this void. The alternative is to allow the Chinese to dominate medical development to the severe detriment of our National Security interests.”
“It should also be noted that the Chinese government is seeking worldwide domination in medical research and the development of bio-weapons to target US citizens and our allies,” Westergaard said.
He added, “Alpha Genesis is a leading provider of NHPs to the US market and has been instrumental in attempting to fill this void. The alternative is to allow the Chinese to dominate medical development to the severe detriment of our National Security interests.”
Human error or intentional act?
Asked by ABC News whether the rapid expansion of Alpha Genesis’ breeding and testing operations might have played a role in the escape of the 43 primates, Westergaard said the cause of the escape remains under investigation, including whether it was the result of “human error” or an “intentional act.”
“All the information we have thus far indicates that this is human error due to an employee failing to secure containment doors behind her, and a third door directly containing the animals, while doing routine cleaning and feeding,” Westergaard said in an email. “The enclosure was brand new and in perfect working order. We continue to investigate in an attempt to determine to the greatest extent possible whether this was or was not an intentional act.”
Westergaard said that immediately after the incident occurred, the employee’s supervisor told her she could be fired if it was determined that no structural failure of the primates’ enclosure led to the incident. Westergaard said the employee walked off the job and has not returned.
As of early Tuesday, four of the escaped primates remained on the loose, Westergaard said. Two were caught Monday, he said.
“The girls from today are in good health and the others continue to thrive,” Westergaard said Monday. “We believe the four monkeys remaining are probably all together either in the area adjacent to our property or somewhere else very close by.”
Mace has requested answers from NIH Director Monica Bertagnolli, USDA Deputy Administrator for Animal Care Sarah Helming, and Acting Director Axel Wolf of the NIH’s Office of Laboratory Animal Welfare. She also noted that this was not the first time problems had arisen at the research lab.
Mace, who told ABC News she is against animal testing, cited in her letter a September 2022 USDA inspection report of Alpha Genesis that found six separate incidents of animals escaping from their primary enclosures between January and August of 2022. Mace also cited escapes dating back to 2014, when more than two dozen monkeys slipped out of the facility, resulting in a fine from the USDA.
The 2022 USDA inspection report, which ABC News reviewed, also found an infant monkey died after becoming entangled in a stretch of gauze material used in an enclosure to hold a water bottle; said two primates were found dead in their enclosures with their fingers entrapped in structures inside their cages; and documented that one animal died from trauma and four others required veterinary care after they were placed in incorrect enclosures and were attacked by other primates unfamiliar with them.
As a result of the inspection, Alpha Genesis, according to the report, took corrective action to secure enclosures and “made significant changes” to avoid putting primates in the wrong enclosures.
The latest USDA routine inspection of Alpha Genesis lab was conducted on May 21 and concluded, “No non-compliant items identified during this inspection,” according to USDA online records.
“This is also true of several other inspections in recent years,” Westergaard said. “For a facility of this size that is quite remarkable.”
Mace said she met with Westergaard last week to discuss the escape and what Alpha Genesis is doing to round up the monkeys.
“It was an interesting conversation,” Mace said. “He tried to tell me how good the primates have it at his facility. And my response was, they have it good until you kill them with disease.”
Asked about the conversation, Westergaard responded: “I spoke to the congresswoman last week and at that time she said that she recognized the economic importance of our company to the people of the Low Country and that as a locally-owned business, she would continue to offer her full support.”
Alternatives to testing primates
Angela Grimes, CEO of Born Free USA, an international wildlife conservation and animal protection organization, told ABC News that her group has sent a letter to Alpha Genesis offering to rehome the escaped primates to its animal sanctuary in South Texas, where more than 200 rhesus macaque monkeys now reside, including some rescued from U.S. research labs. She said an anonymous donor has pledged $250,000 to help move the animals to the sanctuary.
“What we’d like to see is these animals be released to the Born Free USA sanctuary in South Texas, where they can have some of that freedom that they’ve just gotten a taste of,” Grimes said.
Grimes said Alpha Genesis has not responded to her group’s offer.
The nonprofit Born Free USA Primate Sanctuary, a 175-acre facility in Dilley, Texas, has been accredited since 2009 by the Global Federation of Animal Sanctuaries, GFAS executive director Valerie Taylor told ABC News, adding that her group conducts rigorous assessments and inspections of animal sanctuaries across the United States and around the globe to ensure the highest standard of animal care possible. Taylor said U.S. animal sanctuaries undergo accreditation every three years and that her organization recently visited the Born Free USA sanctuary as part of the reaccreditation process.
“We meet and exceed GFAS’ highest standards,” Grimes said.
Grimes said the medical research industry needs to research alternatives to subjecting primates to experimental testing of deadly diseases.
“I understand human health is important, but I also look at the other viable alternatives that are out there that do not result in the suffering and death of animals,” Grimes said.
Westergaard said testing of primates is necessary, though.
“There is no safe or effective way to make the leap from simpler model organisms like mice and rats to humans without using NHPs as an intermediary,” Westergaard said. “The therapeutics created using NHPs as research models directly lead to lifesaving and life-prolonging treatments and cures for human disease. Without NHPs as a research model, the world would still be ravaged with wide-spread polio, smallpox wouldn’t be eradicated, and HIV would still be a death sentence.”
(NEW YORK) — Infant mortality rates remained relatively unchanged from 2022 to 2023, but racial and ethnic disparities still persist, new provisional federal data released early Thursday finds.
The U.S. provisional infant mortality rate in 2023 was 5.61 infant deaths per 1,000 live births, unchanged from the 2022 rate, according to a report from the Centers for Disease Control and Prevention’s National Center for Health Statistics (NCHS).
The report also found that infants born to Black mothers still died at much higher rates than those born to white and Asian mothers — more than double the rate of white infant mortality, according to the CDC.
Additionally, changes in the neonatal mortality rate from 3.59 deaths per 1,000 live births in 2022 to 3.65 deaths per 1,000 live births in 2023, and the postneonatal mortality rate from 2.02 deaths per 1,000 live births to 1.96 deaths per 1,000 live births from 2022 to 2023 were not seen as statistically significant, the report’s authors said.
Neonatal refers to the first four weeks of an infant’s life and postneonatal refers to the period between 28 days and 364 days after birth.
Dr. Danielle Ely, co-author of the report and a health statistician at the NCHS, said 2022 was the first year there was a significant increase in the infant mortality rate in about 20 years. That the rate did not increase in 2023 shows the rise in 2022 was likely not a fluke, she said.
“So what we’re seeing is that what we were hoping would be just a one-year blip is now a two-year higher rate,” she told ABC News. “It is unfortunate that it did not go down again to where it was in 2021 at least or at least down from 2022. It just quite literally stayed the same, the infant mortality did.”
Black infants died at a rate of 10.9 infant deaths per 1,000 live births, more than double the rate of 4.5 deaths per 1,000 live births for white women and 3.4 deaths per 1,000 live births for Asian women, per the CDC data.
Infants born to American Indian and Alaska Native women also had higher rates than white and Asian women at 9.2 deaths per 1,000 live births, according to the report.
Data also showed infants born to Hawaiian or Pacific Islander women died at a rate of 8.2 deaths per 1,000 live births, and those born to Hispanic women died at a rate of 5.0 deaths per 1,000 live births.
Why racial disparities continue to persist is “the $100 million question,” Dr. Kirsten Bechtel, a pediatric emergency medicine physician at Yale New Haven Children’s Hospital and an expert in infant mortality, told ABC News.
“One of things that’s great about this data is that it helps us work backward. It’s like the canary in the gold mine,” Bechtel, who was not involved in the report, said. “Death is an outcome that everyone agrees on is a problem, but why that problem happens is oftentimes subject to vigorous discussion.”
She said one reason behind the disparities could be that Black mothers have a higher rate of pre-term birth, and pre-term birth is associated with higher infant mortality.
“That has a lot to do with access to timely prenatal care,” Bechtel said. “Trying to get folks access to timely care during pregnancy and timely care that is evidence-based. We also know there is some elements of structural racism that is built into some of the care these women receive.”
Bechtel said the findings show that pregnant people need to be supported financially with access to medical care and by the community helping take care of a child.
“Raising a child can be very daunting, especially if you have socioeconomic challenges or you have to go to work and you can’t take time off after your baby’s birth,” she said. “So we really need to look at policies that support pregnant people.”
Harika Rayala, M.D., MSJ, is a neurology resident physician at the University of Virginia and a member of the ABC News Medical Unit.
