Michigan resident dies of rabies after undergoing organ transplant in Ohio: Officials
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(LANSING, Mich.) — A Michigan resident has died of rabies after apparently undergoing an organ transplant, health officials said.
The Michigan Department of Health and Human Services (MDHHS) told ABC News that the patient underwent an organ transplant at an Ohio hospital in December 2024.
The resident died in January 2025 and “a public health investigation determined they contracted rabies through the transplanted organ,” MDHHS said.
The organ donor was not a Michigan or Ohio resident, according to MDHHS. The department said it is not providing any additional information about the resident or the donor.
This is a developing story. Please check back for updates.
(LUBBOCK, Texas) — The measles outbreak in western Texas is continuing to grow with 20 additional cases confirmed, bringing the total to 279 cases, according to new state data published Tuesday.
Almost all of the cases are in unvaccinated individuals or in individuals whose vaccination status is unknown, according to the Texas Department of State Health Services (DSHS). Just two cases are among fully vaccinated individuals. At least 36 people have been hospitalized so far, the state said.
In the Texas outbreak, children and teenagers between ages 5 and 17 make up the majority of cases, at 120, followed by children ages 4 and under making up 88 cases, the DSHS data shows.
“Due to the highly contagious nature of this disease, additional cases are likely to occur in the outbreak area and the surrounding communities,” the DSHS said in its update.
Two likely measles deaths have been reported so far in the U.S. The first reported death was an Texas, according to the DSHS. The child did not have any known underlying conditions, according to the department.
This is a developing story. Please check back for updates.
(WASHINGTON) — Five years ago, the World Health Organization declared the COVID-19 outbreak to be a pandemic, leading to stay at-home orders and shutdowns across the U.S. and world.
The nation looks much different since then, and scientists and researchers have learned a lot about the virus, including how it infects people, the best forms of treatment and what puts someone at risk for long COVID.
There are still many questions, however. Health care professionals are working to find answers, such as how many people have truly died, how long the virus spread undetected in the U.S. and its origins.
“We know this emerged in China, around the city Wuhan. That’s very clear,” Dr. Cameron Wolfe, an infectious diseases specialist and a professor of medicine at Duke University School of Medicine, told ABC News. “We know when [the] medical community identified it, but we don’t know quite how long it was circulating before then. I think it’s caused some of the consternation.”
How many people have died of COVID-19?
As of March 6, at least 1,222,603 Americans have died of COVID-19, according to data from the Centers for Disease Control and Prevention.
The U.S. currently has the highest number of deaths of any country in the world, according to the WHO.
Experts, however, believe the true death toll is higher.
“More than a million people is a tragedy into itself, let’s start with that obvious fact,” Wolfe said. “I think the numbers are really hard to pin down for one key reason.”
Determining the exact cause of death can be complicated, Wolfe explained. Someone could die of COVID pneumonia — a lung infection caused by the virus — or die from a heart attack after contracting COVID.
Another example is an older adult who contracts COVID-19. They may become dehydrated, break a bone — because dehydration negatively impacts bone health — and suffer fatal complications, Wolfe said.
“How you count those outcomes is really important because, to me, that person wouldn’t have had their heart attack or that person wouldn’t have become dehydrated and fallen over and landed in the hospital if not for COVID triggering that event in the first place,” he said. “So, I actually think it’s really important to count those as COVID-associated mortalities, but they’re hard to count. They’re hard to track.”
Globally, more than 7 million people have died due to COVID-19, WHO data shows, although the agency says the pandemic caused an estimated 14.83 million excess deaths around the world in 2020 and 2021.
What is the mechanism behind long COVID
Scientists are not sure what causes long COVID but have identified certain risk factors such as an underlying health condition. Long-COVID symptoms can last for weeks, months or even years and can include — but are not limited to — fever, fatigue, coughing, chest pain, headaches, difficulty concentrating, sleep problems, stomach pain and joint or muscle pain, according to the CDC.
Research has found that patients with long COVID tend to have lower cortisol levels and lower testosterone levels.
“There are several questions that we still do not have answers for. What is the mechanism of the disease? Why do some people get more sick than others?” Dr. Fernando Carnavali, an internal medicine physician and a member of the team at Mount Sinai’s Center for Post-COVID Care, told ABC News.
Carnavali said scientists are using machine learning to study groups of long COVID patients in an attempt to determine the mechanisms that cause the condition.
“Do we have a single answer? Not as of yet, and most likely, perhaps we’ll have more than one answer,” he said.
Carnavali said the mechanism may not be the same for every long COVID patient. Additionally, people may have different symptoms due to different genetic predispositions.
“Some of the deficits that we have five years ago still remain, but I think that we should all understand and be hopeful that … researchers using machine learning will [provide] us some of the answers that we need as clinicians,” he said.
When did COVID enter the United States?
It’s still not exactly clear when the virus first entered the U.S. The first confirmed case in the country was Jan. 20, 2020, in a man in his 30s in Washington state, who developed symptoms after a trip to Wuhan.
However, studies have suggested the virus may have been circulating undetected for months beforehand.
Although the WHO was first notified on Dec. 31, 2019, about the mysterious pneumonia-like illness that originated in Wuhan, experts say it is likely that in an age of global travel, the virus was in the U.S. before then.
“It’s more likely circulated before Jan. 1 [2020]. It doesn’t seem unreasonable, November, December,” Dr. Lisa Olson-Gugerty, an associate teaching professor for Syracuse University and practicing family nurse practitioner in emergency medicine, told ABC News. “COVID masquerades itself as a flu-like illness, upper respiratory-like illness, like many other viral illnesses. It’s not easy to say, ‘Hey, I think this must be a new thing, and I’m going to tell everyone.'”
She went on, “I think it takes a bit of collective time to recognize a new viral strain, and it doesn’t seem unreasonable [there were] cases that could have been recognized as COVID before the date of release of information.”
Where did the virus come from?
There are two theories about where the virus, known as SARS-CoV-2, originated.
At least four U.S. agencies believe the virus was a result of natural transmission and that the virus jumped from animals to humans at a wet market.
The FBI, the CIA and the Department of Energy – the latter with “low confidence” — believe the COVID-19 pandemic “most likely” was the result of a laboratory leak in China.
Additionally, an April 2023 report from Senate Republicans conceded that “both hypotheses are plausible” but that the evidence points to the virus emerging from an accidental lab leak in Wuhan — and there may even have been multiple leaks.
If the virus did come from an animal, there are questions about which species may have spilled the virus over from animals to humans.
“I’ve seen a lot of conflicting information,” Olson-Gugerty said. “Did it come from a bat? Did it get into raccoon dogs or civet cats? Or was it a lab-created virus in Wuhan, China There does seem to be a jury that’s out.”
Wolfe said we may never know the true origins of SARS-CoV-2, but trying to answer the question helps scientists and public health professionals learn how to mitigate the spread so a pandemic — or even widespread illness — doesn’t happen again.
“This was the same question that happened during the Ebola pandemic, when we had to say, ‘Where did this come from? How can we educate people to minimize this future risk?'” he said. “It was important to examine where COVID-19 came from to try and put things in place that would stop that happening.”
He added, “We certainly, I would say, have better safety mechanisms now in place … so there are some good things that have come out of this.”
Purdue Pharma headquarters; Victor J. Blue/Bloomberg via Getty Images
(NEW YORK) — The company and once-prominent family behind the drug OxyContin agreed Thursday to increase their financial contribution to resolve mass opioid litigation.
The Sacklers and Purdue Pharma boosted their settlement contribution to $7.4 billion after the U.S. Supreme Court overturned a prior settlement in June 2024. If approved, the new plan would end the costliest corporate bankruptcy resulting from the U.S. opioid crisis.
Purdue, under the leadership of the Sackler families, invented, manufactured and aggressively marketed opioid products for decades, according to the lawsuits. States and cities across the country said it fueled waves of addiction and overdose deaths.
The pharmaceutical company introduced OxyContin, a brand name of oxycodone, in the 1990s and filed for chapter 11 bankruptcy in 2019 after the company was sued thousands of times.
Under the settlement terms, the Sacklers’ control of Purdue Pharma ends. The $7.4 billion will go directly to communities across the U.S. — including states, counties, cities and territories — over the next 15 years to support opioid addiction treatment, prevention, and recovery programs.
“Families throughout New York and across the nation are suffering from the immense pain and loss wrought by the opioid crisis,” said New York Attorney General Letitia James, whose office helped negotiate the settlement agreement.
“The Sackler family relentlessly pursued profit at the expense of vulnerable patients, and played a critical role in starting and fueling in the opioid epidemic,” she continued. “While no amount of money will ever fully repair the damage they caused, this massive influx of funds will bring resources to communities in need so that we can heal.”
Purdue Pharma planned to exit bankruptcy last year under terms that gave the Sacklers a full release from all civil opioid claims even though they themselves were not declaring bankruptcy. In return, the Sacklers agreed to pay $6 billion.
The Supreme Court rejected the attempt by the Sacklers to use Purdue Pharma’s bankruptcy to shield themselves from liability.
Under the new terms, a significant amount of the settlement funds will be distributed in the first three years, with the Sacklers paying $1.5 billion and Purdue paying nearly $900 million in the first payment, followed by $500 million after one year, an additional $500 million after two years, and $400 million after three years.
A board of trustees selected by participating states in consultation with the other creditors will determine the future of the company. Purdue will continue to be overseen by a monitor and will be prevented from lobbying or marketing opioids.
“This story is about a family of cruel billionaires who believed they were above the law, pursued by states who never backed down,” Connecticut Attorney General William Tong said Thursday. “Today, we are forcing Purdue Pharma and the Sackler family to pay $7.4 billion for their role in igniting one of the most devastating public health crises in American history.”
Purdue Pharma said in a statement to ABC News, “We are extremely pleased that a new agreement has been reached that will deliver billions of dollars to compensate victims, abate the opioid crisis, and deliver treatment and overdose rescue medicines that will save lives. We have worked intensely with our creditors for months in mediation, and we are now focused on finalizing the details of a new Plan of Reorganization, which we look forward to presenting to the bankruptcy court.”
