E coli outbreak linked to McDonald’s Quarter Pounders declared over: CDC
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(NEW YORK) — The deadly E. coli outbreak linked to McDonald’s Quarter Pounders was declared over on Tuesday by the Centers for Disease Control and Prevention.
In total, 104 people reported falling ill across 14 states with about one-third of them being hospitalized, according to the CDC.
The true number of people who got sick was likely much higher because many people recover from E. coli without medical care and are never tested, the CDC noted.
Americans between ages 1 and 88 were affected in the outbreak, according to he CDC. Colorado had the greatest number of cases with at least 30 people falling ill. The state also reported one death.
An outbreak notice was first released by the CDC in late October. Evidence from health officials’ investigation at the time showed that slivered onions served on Quarter Pounders were a likely source of contamination.
Nearly all the people who fell ill and were interviewed by health officials reported eating at McDonald’s and the overwhelming majority remembered eating a menu item that contained the fresh, slivered onions, according to the CDC.
The fast food chain’s distributor of the onions, Taylor Farms, initiated a voluntary recall of the onions in late October. McDonald’s stopped using the ingredient and removed the Quarter Pounder entirely off the menu in a dozen states.
The latest reported illness was on Oct 21. All the confirmed cases occurred before the onions were recalled and the ingredient was taken off of the McDonald’s menu at some locations, according to health officials.
The fast-food chain is no longer serving the recalled onions and there “does not appear to be a continued food safety concern related to this outbreak,” the U.S. Food and Drug Administration said on Tuesday. The agency also noted that its investigation is now closed.
McDonald’s North America chief Impact officer Michael Gonda and chief supply chain officer Cesar Piña shared a message on Tuesday, saying the announcements from the CDC and FDA provide “certainty and validation” that the outbreak is over and the risk to the public has remained low since late October.
While the issue had been fully contained — and any contaminated product associated with this issue had been removed from our supply chain as of Oct. 22, 2024 — it can now be classified as “closed” and remediated,” the message read, in part.
(NEW YORK) — Moderna has been awarded approximately $590 million from the federal government to help speed up the development of an mRNA-based bird flu vaccine, alongside other influenza vaccines, health officials announced Friday.
The U.S. Department of Health and Human Services (HHS) said in a press release that the funding will allow the pharmaceutical company to accelerate the development of an H5N1 mRNA influenza vaccine “that is well matched to strains currently circulating in cows and birds and expands the clinical data supporting the use of mRNA vaccines that may be needed if other influenza strains emerge with pandemic potential.”
Moderna said the funding will support the expansion of clinical studies “for up to five additional subtypes of pandemic influenza.”
The U.S. government previously awarded the vaccine manufacturer $176 million in July 2024 to help expedite the development of an mRNA vaccine that could be used for bird flu.
mRNA technology is the same type that was used in the development of some COVID-19 vaccines. While some vaccines use a weakened or inactive virus to stimulate an immune response, mRNA vaccines teach the body how to make proteins that can trigger an immune response and fight off an infection.
Researchers can often design mRNA vaccines more quickly than they can produce the live or weakened pathogens needed for a live-attenuated or inactivated vaccine.
The federal government already has two bird flu vaccine candidates, which use traditional vaccine technology, available in the nation’s stockpile. Officials previously noted they’d have 10 million ready-to-use doses within the beginning of 2025. Vaccines were being stockpiled as a precaution.
“Avian flu variants have proven to be particularly unpredictable and dangerous to humans in the past. That is why this response has been a top priority for the Biden-Harris Administration and HHS,” HHS Secretary Xavier Becerra said in a statement on Friday. “Accelerating the development of new vaccines will allow us to stay ahead and ensure that Americans have the tools they need to stay safe.”
Bird flu cases in humans have been spreading across the country since April 2024 with 67 confirmed cases as of Friday, according to the Centers for Disease Control and Prevention (CDC).
The first death of a human bird flu patient was reported in Louisiana earlier this month. The patient was over the age of 65 and had underlying medical conditions, according to health officials.
Most human cases have occurred after coming into contact with infected cattle, infected poultry farms or other culling operations.
The CDC and other public health officials say there is currently no evidence of human-to-human transmission and the risk to the general public is low.
ABC News’ Mary Kekatos contributed to this report.
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(NEW YORK) — As world leaders mourn the death of former President Jimmy Carter and remark on his political and policy legacy, doctors are remembering his efforts to prevent disease, and his legacy in furthering global public health.
The 39th president spent five decades working to eradicate a parasitic disease, helped organize a major-drug donation program, and made advancements addressing the mental health crisis in the U.S.
Dr. Julie Jacobson, currently a managing partner of the nonprofit Bridges to Development, helped to provide funding for the Carter Center’s work in the Americas, Nigeria and Ethiopia while she worked for the Bill & Melinda Gates Foundation for over a decade.
“He was hugely influential, I think particularly for the diseases that most of the world doesn’t appreciate even exist,” Jacobson told ABC News of Jimmy Carter’s work. “He was a true champion for the neglected tropical diseases, which are some of the most common infections of people who live with the least resources. And he found these diseases and then really wanted to do something about them, and used his voice, his influence, his passion, to continue to push forward where others were really not interested.”
Near-eradication of Guinea worm disease
Following his loss to Ronald Reagan in the 1980 presidential election, Carter founded the Carter Center in 1982, a non-profit organization that “seeks to prevent and resolve conflicts, enhance freedom and democracy, and improve health,” according to the Center’s website.
Among the organization’s many efforts, the Carter Center helped spearhead a successful international campaign with the goal of eradicating dracunculiasis, also known as Guinea worm disease, a parasitic infection caused by consuming contaminated drinking water.
Water from ponds or other stagnant bodies of water can contain tiny crustaceans commonly known as water fleas, which in turn can be infected with Guinea worm larvae, according to the Centers for Disease Control and Prevention (CDC).
About one year after infecting a human host, the Guinea worm creates a blister on the skin and emerges from it, which can cause burning pain, fever and swelling, according to the CDC and the World Health Organization.
“Nobody else wanted to take it on,” Jimmy Carter told ABC News’ George Stephanopoulos during a 2015 interview on “Good Morning America”. “So, I decided to take it on.”
In 1986, Guinea worm disease afflicted 3.5 million people every year in 21 African and Asian countries. Disease incidence has since been reduced by 99.99%, to just 14 “provisional” human cases in 2023, according to the Carter Center.
Jacobson said that success is even more remarkable because there are no vaccines available to prevent Guinea worm disease and no drugs to treat it. Tracking Guinea worm disease, according to Jacobson, involves following possible cases for a year to determine if they are infected, checking to see if infected humans have any infected water sources near them, and monitoring the community as a whole.
“To think that you could eradicate a disease without any tools is really still just a crazy idea, but he did it with perseverance and working with people in the grassroots within communities and putting together teams of people to go and work with people in those communities and empower the communities,” Jacobson said.
The Carter Center says if efforts are successful, Guinea worm disease could become the second human disease in history to be completely eradicated, after smallpox, and the first to be done without the use of a vaccine or medicine.
Carter told ABC News during the 2015 interview that eradicating the disease entirely was his goal: “I think this is going to be a great achievement for, not for me, but for the people that have been afflicted and for the entire world to see diseases like this eradicated.”
Mass drug distribution for river blindness
The Carter Center also works to fight other preventable diseases, including the parasitic infections schistosomiasis and lymphatic filariasis – more commonly known as snail fever and elephantiasis, respectively – as well as trachoma, which is one of the world’s leading causes of preventable blindness. It’s also working with the governments of Haiti and the Dominican Republic to eliminate lymphatic filariasis and malaria from the island of Hispaniola, which both countries share and which is “the last reservoir in the Caribbean for both diseases,” according to the Carter Center.
Carter and his organization also played a part in organizing a major drug-donation program to help eliminate onchocerciasis, also known as river blindness, which is transmitted to human through repeated bites of infected blackflies, according to the CDC.
Pharmaceutical company Merck & Co. had been implementing field studies in Africa which showed that the drug ivermectin was effective at treating river blindness in humans. The Carter Center partnered with Merck to mass-distribute ivermectin, brand name Mectizan, “as much as needed for as long as needed” in Africa and Latin America. To date, the Carter Center has assisted in distributing more than 500 million treatments of Mectizan, according to Merck.
In 1995, Carter negotiated a two-month cease-fire in Sudan to allow health care workers there to more safely help eradicate Guinea worm disease, prevent river blindness, and vaccinate children against polio.
“When we have known solutions, it is ethical to make sure they’re available to the people who need it most,” Dr. Usha Ramakrishnan, chair of the Department of Global Health at Emory University’s Rollins School of Public Health, told ABC News. “And that’s where we were with river blindness. There was a treatment, but improving access to medications, making it affordable, reaching the people they need was very much along the lines of the work [the Carter Center] was doing.”
Addressing mental health
Carter was also committed to tackling mental health issues. During his presidency, he created the Presidential Commission on Mental Health, which recommended a national plan to care for people with chronic mental illness.
Although it was never adopted as policy by the Reagan administration, the plan’s recommended strategies were adopted by some mental health advocacy groups to “make gains in the 1980s,” according to one study.
Carter also signed into law the Mental Health Systems Act of 1980, which provided funding to community mental health centers.
After his presidency, Carter and former first lady Rosalynn Carter continued working to improve access to mental health.
Ramakrishnan said the Carters’ work helped to reduce some of the stigma associated with mental health.
“There continues to be a lot of stigma, but they truly got it out [in] the conversation and mainstreaming mental health as an important aspect of health and well-being,” Ramakrishnan said. “There’s still a lot of challenges, and there are many capable people that they have mentored and trained who are carrying that mantle forward.”
After more than two years of gender-affirming treatments, LW, the Tennessee teenager behind a landmark case at the U.S. Supreme Court, says, “I feel normal now.” (ABC News)
(NASHVILLE) — The transgender Tennessee teenager behind a historic hearing at the U.S. Supreme Court this week doesn’t want to show her face on television but is eager to speak about a case she says has the potential to make thousands of American kids feel “seen” for who they are.
“The court has definitely ruled in ways that would make me think that they don’t exactly value bodily autonomy, but I have heard that they’ve been a little bit better about trans cases than people would think,” said 16-year-old LW in an exclusive interview with ABC News alongside her parents Samantha and Brian Williams.
The court on Wednesday will hear the Williams family’s challenge to Tennessee’s 2023 ban on gender-affirming medical treatments for minors, including puberty-blocking medication and hormone therapies that have dramatically improved LW’s quality of life.
While the medications have been used safely to treat minors of all genders for years, they are now prohibited in Tennessee when used to treat trans kids struggling with gender dysphoria, the distress experienced when one’s gender assigned at birth is different from one’s sense of identity.
“It’s not very comfortable being trapped in [your body] because it just doesn’t feel like you,” said LW, who reports significant improvement since beginning the treatments in 2022.
Since the state law took effect, LW now has to take time away from school to make a 10-hour round trip out of state to continue receiving care. The travel has also been a costly and time-consuming burden, her parents say.
“It would definitely be horrible for me to have to continue to go out of state to get care,” said LW. “I feel normal now.”
Backed by the American Civil Liberties Union, the Biden administration, and major American medical associations, the Williamses sued Tennessee last year alleging the ban on certain gender-affirming treatments for minors discriminates on the basis of sex and overrides the rights of parents to make medical decisions for their children.
“Our state legislature had made such a big deal out of parents’ rights during COVID, about masks and vaccines that that’s for parents to decide these medical decisions for their children,” Samantha Williams said. “And then they made this medical decision for our child.”
State lawmakers who support the law, SB1, say it is meant to protect kids from potentially irreversible effects from treatment and that contradictory scientific evidence and uncertainty about long-term adverse consequences warrant caution.
“We made the policy decision on behalf of our constituents that in Tennessee we think this is a risky procedure,” said state Sen. Jack Johnson, the Senate GOP leader who sponsored the bill. “It is our role as policymakers here in the state of Tennessee to set those guardrails.”
The American Academy of Pediatrics says the effects of puberty blockers are not permanent if treatment is discontinued and that many effects of hormone therapy can also be reversed. Long-term risks may include fertility challenges and possible harm to bone density, but the Academy says those risks require further study.
Worldwide, several countries which had previously embraced the treatments for transgender children have subsequently reversed course, citing unclear data about their purported benefits and alleged harms. In many of those places, the treatments remain available, but on a much more limited basis.
In Tennessee, there are an estimated 3,000 transgender teenagers between ages 13 and 17, according to the Williams Institute at UCLA Law School, which has analyzed Census data. It is not known how many were receiving treatments that are now outlawed or how many suffered alleged harm.
A study published in the medical journal JAMA Pediatrics in October 2024 found the overwhelming majority of participants in a long-term survey of 220 transgender youths reported high levels of satisfaction and low levels of regret in the three to five years after receiving puberty blockers and hormone therapy.
Major American medical associations have for more than a decade endorsed the use of puberty blockers and hormone therapy as part of “individually tailored interventions” to support trans kids and affirm their sense of self.
“It all begins and ends with science. This is not about any sort of agenda,” said Dr. Ben Hoffman, president of the American Academy of Pediatrics, in an interview with ABC.
Clinical practice guidelines from the American Endocrine Society — based on more than 260 research studies — recommend consideration of medications to treat gender dysphoria in young people but waiting until a child reaches adulthood to consider gender-affirming surgery.
“It’s crucial that there be a deep understanding of both the risks and benefits, and truly informed consent,” Hoffman said. “And for that reason, it is, by definition, going to take months or years.”
The Williams family said the decision to use medication to delay LW’s puberty followed months of careful consultation with medical experts and mental health providers. They said they grew worried that masculine changes to LW’s body would compound her gender dysphoria.
“There is this time clock sitting here,” said Brian Williams. “The kids can go through puberty and it can have permanent effects on them. So these two things you’re trying to balance at the same time.”
“She’s not suicidal, but she shouldn’t have to be suicidal, right?, to get the care that she needs,” added Samantha Williams. “When that really hit me, I was like, ‘OK, let’s do blockers. Let’s get moving.'”
More than a year later, LW began receiving hormone therapy to better align her body with her gender identity. The course of treatment led to a reduction in discomfort.
“That was incredibly helpful,” LW said. “I feel amazing after that. You know, maybe it’s just because the gender dysphoria was so bad.”
The outcome of the case U.S. v. Skrmetti could have a sweeping impact on health care for the more than 300,000 American teens who identify as transgender, as well as the broader LGBTQ community.
“This is one of the most significant LGBTQ cases to ever reach the Supreme Court. I think this is an inflection point,” said Chase Strangio, the ACLU attorney representing the Williams family. He will be the first openly transgender person to argue a case before the nation’s highest court.
“Is this going to be a Bowers v. Hardwick type moment that sets off years of government legitimized discrimination against LGBTQ people? Or, is this going to be a Bostock moment that clarifies what we all have been assuming all this time, which is that LGBTQ people are protected under the Constitution and civil rights laws,” Strangio said.
In its 1968 decision in Bowers, the court upheld state laws criminalizing private same-sex conduct; it was overturned in 2003. The Court’s 2020 decision in Bostock v. Clayton County found that employment discrimination on the basis of sexual orientation and gender identity is illegal.
Twenty-six states have laws banning gender-affirming treatments for minors, according to the Human Rights Campaign, an LGBTQ advocacy group.
“What concerns me as a physician is that legislators are going to be able to make decisions about a diagnosis, which is very unusual. I mean, that really hasn’t happened,” said Dr. Susan Lacy, a physician who specializes in hormone management and transgender care for teens and adults at her private practice in Memphis.
Lacy, who is also a party to the Supreme Court case, agrees with Tennessee lawmakers that more research is needed on gender-affirming treatments for minors, but that a debate over the data shouldn’t deny patients the chance to make an informed decision of their own.
“I think the most compelling thing is to listen to the patients,” Lacy said. “I have about 700 transgender patients out of about 3,000 total patients, and I have not seen anybody have a serious complication — not one.”
“I think we’re just at a point where we’re still in the process of treating people and having studies that will give us more and more data to support this treatment,” she said.
Johnson said he hopes the Supreme Court will uphold an appeals court ruling that affirmed Tennessee’s right to impose restrictions on treatments for transgender minors.
“States should be the laboratories of democracy,” he said. “We should be making the vast majority of decisions about what’s best for our people, our constituents here in the statehouse.”
The Williams family says care that has improved the life of their daughter should not be up for political debate.
“I want to listen to the doctors. I want to listen to my kid. I want to take care of her, you know?” Brian Williams said.
