Surgeon general warns of link between alcohol consumption and cancer risk
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(NEW YORK) — The U.S. Surgeon General issued an advisory on Friday warning of a link between alcohol consumption and cancer risk.
Alcohol consumption is the third leading preventable cause of cancer in the United States, after tobacco and obesity, according to the Surgeon General’s advisory.
For some cancers, including breast, mouth, and throat cancers, the risk of developing cancer may increase with one or fewer drinks per day, the advisory states.
Despite a growing body of evidence, fewer than half of Americans recognize alcohol consumption as a risk factor for cancer, according to the advisory.
A person’s risk of developing cancer due to alcohol consumption is also determined by other factors, including biological, economic, environmental and social, the advisory says.
“Alcohol is a well-established, preventable cause of cancer responsible for about 100,000 cases of cancer and 20,000 cancer deaths annually in the United States – greater than the 13,500 alcohol-associated traffic crash fatalities per year in the U.S. – yet the majority of Americans are unaware of this risk,” U.S. Surgeon General Dr. Vivek Murthy said in a statement. “This Advisory lays out steps we can all take to increase awareness of alcohol’s cancer risk and minimize harm.”
This is a developing story. Please check back for updates.
(NEW YORK) — The rates of late-stage breast cancer at diagnosis have risen among women in all racial and ethnic groups, but Black women have been hit the hardest, according to a new study published in the journal Radiology.
The study, which looked at data from 2004 to 2021, found that advanced breast cancer rates have risen among women of all ages, with the sharpest increases in young women aged 20 to 39, and women over 75.
Black women experience advanced diagnoses 55% more often than white women and are more likely to die from the disease, the study found.
While mammography does save lives by catching cancer earlier, fewer than 70% of eligible women are up to date on their screenings, the study found.
This trend is particularly alarming because early detection significantly improves survival. Five-year survival rates drop drastically from 99% for early-stage breast cancer to just 31% when the cancer is more advanced and has already spread to other parts of the body, the study found.
However, disparities persist despite Black women having similar self-reported mammography use rates as white women.
“Black women tend to have more aggressive breast cancers, including a higher rate of triple-negative breast cancers,” study co-author, Edward Hendrick, Ph.D., clinical professor of radiology at the University of Colorado told ABC News. “There may also be differences in how findings are acted upon, reflecting barriers to high-quality care.”
The COVID-19 pandemic made things worse as well, Hendrick noted, with many women skipping or delaying mammograms.
“Volumes at screening sites for the year 2020 were down as much as 90% from 2019 levels,” he said. “These missed screenings contributed to higher rates of advanced breast cancers in 2021 and likely subsequent years.”
The study also pointed to other possible reasons for the uptick in later-stage diagnoses.
“Obesity in post-menopausal women increases breast cancer risk, as does prolonged exposure to estrogen from early periods or late menopause,” explained study co-author, Debra L. Monticciolo, M.D., a professor of radiology at Texas A&M University.
She added that physicians could help by offering a breast cancer risk assessment to their patients starting at age 25. Identifying high-risk women early would help catch cancers sooner, she said.
Despite the concerning statistics, the study suggested that solutions are within reach. Increasing screening rates, expanding healthcare access, and ensuring follow-up care after abnormal mammograms could make a difference.
“Improving equity in care is critical to saving lives,” Monticciolo said. “By prioritizing access to care for all and emphasizing the importance of early detection, we believe this trend of rising late-stage diagnoses can be reversed.”
Late-stage breast cancer diagnoses are not just statistics — they reflect missed opportunities for prevention and early treatment, Hendrick added.
“We could benefit from greater public awareness of the importance of catching breast cancer at its earliest, most curable stages,” he said.
Breast cancer accounts for about one in three new cancer diagnoses in women every year, according to the latest American Cancer Society statistics. More than 40,000 American women die from the disease yearly.
Esther Zusstone, MD, is a radiology resident at NYU Langone, and a member of the ABC News Medical Unit.
(YEMASSEE, SC) — With four primates still on the loose after 43 of them escaped on Nov. 6 from the Alpha Genesis Inc. research laboratory in South Carolina, the Low Country facility has come under intense scrutiny.
Animal rights groups have cited the company’s history of violations and previous monkey breakouts; a member of Congress has called for an inquiry into its oversight by multiple federal agencies; and residents voiced concern the furry fugitives might spread disease throughout their community.
On top of it all, Alpha Genesis founder and CEO Gregory Westergaard told ABC News his company is investigating whether the release of the monkeys was “an intentional act” by an employee.
The quest for freedom by the pack of young female rhesus macaques coincides with the rapid expansion of the 100-acre Alpha Genesis facility and is casting light on a disruption in the U.S. medical research industry that sounds like a plot for a science fiction thriller. A 2023 report sponsored by the National Institutes of Health warned of a crisis involving the Chinese government that “undermines the security of the nation’s biomedical research enterprise.”
The case of the absconding primates has also raised questions about why the amount of federal contracts received by the testing and breeding operation has jumped more than 160% since 2021. According to USASpending.gov, a government website that tracks federal spending, the company has been granted $19 million in federal contracts this year alone.
“It’s shocking how much money is being spent on testing primates,” Rep. Nancy Mace, R-S.C., told ABC News.
Mace’s district encompasses the Beaufort County community of Yemassee, where the 6,701 primates housed at the sprawling Alpha Genesis facility nearly triple the number of town residents.
In a formal letter to the NIH, the agency that funds laboratory research, and the U.S. Department of Agriculture, which inspects and regulates breeding facilities, Mace expressed “very urgent concerns regarding federal oversight of Alpha Genesis.” Mace said the prolonged attempts to recapture all of the primates are “placing the animals and my constituents at risk.”
“A lot of constituents were concerned about whether or not the primates that escaped were sick or ill, or have been tested on,” Mace told ABC News. “There were a lot of folks concerned about the facility being a breeding facility and the testing that goes on there as well.”
The escape highlights an ‘issue of national security’
The incident some locals have referred to as “the great escape” has illuminated the international crisis hitting the animal research industry that Alpha Genesis’ Westergaard said has become “an issue of national security.”
In 2020, the Chinese government, the world’s primary breeder of research monkeys, banned the exports of nonhuman primates (NPH) to labs in the United States and elsewhere, triggering an international shortage of the animals just as research scientists were scrambling to come up with vaccines to combat the COVID-19 pandemic, according to a May 2023 report by National Academy of Engineering and National Academy of Medicine.
Primates, according to the NIH-supported report, are valuable in answering certain research questions because of their genetic, anatomic, physiologic and behavioral similarities to humans. However, the China ban on exporting research animals exacerbated the shortage and stalled NIH-funded research, according to the report.
The report concluded that the United States “needs to prioritize expansion” of domestic primate breeding programs.
“Relying on importing these animals from other countries is unsustainable, and dependence on international sources undermines the security of the nation’s biomedical research enterprise,” the report warned.
In 2021, the National Primate Research Centers could not meet two-thirds of researcher requests for rhesus macaques, according to the report.
“Researchers also face increased wait times for animals, and costs have risen 10% to 200% for a single animal, depending on the species,” the report said.
What we know about Alpha Genesis’ research
The crisis prompted Alpha Genesis to increase its domestic breeding of research primates. According to Rep. Mace, the company also manages the NIH’s so-called “Monkey Island” on Morgan Island in Beaufort County, which holds another 3,300 primates.
Westergaard told ABC News that Alpha Genesis employs 275 people, plus 30 or so contractors.
In addition to breeding lab monkeys, Alpha Genesis provides researchers across the country with biological products and materials, including serum, plasma, whole blood and tissue samples from a wide variety of research species, according to the company’s website. The private company’s researchers have helped develop several therapeutic drugs and vaccines, including those to treat the COVID-19 virus.
According to NIH online records provided to USASpending.gov, the crisis appears to be in accord with a boost in federal contracts Alpha Genesis has received, jumping from $7.3 million in 2021 to $12.3 million in 2022, $14.2 million in 2023 and $19 million this year.
Primates are worth up to $30,000 each
“The price of research monkeys has indeed increased a great deal since the Chinese banned all exports,” Westergaard said in an email to ABC News. “Prior to the ban monkeys sold for around $4K – $6K, after the ban prices have increased to $10K – $30K+ due to increased costs of raising animals in the US compared to China. An important point to note is that the shortage remains severe and a great deal of research in the US simply cannot be done because animals are not available at any cost.”
Westergaard said some suppliers of laboratory primates have turned to the illegal sourcing of wild-caught monkeys from Cambodia, “which we have not done.”
“It should also be noted that the Chinese government is seeking worldwide domination in medical research and the development of bio-weapons to target US citizens and our allies,” Westergaard said.
He added, “Alpha Genesis is a leading provider of NHPs to the US market and has been instrumental in attempting to fill this void. The alternative is to allow the Chinese to dominate medical development to the severe detriment of our National Security interests.”
“It should also be noted that the Chinese government is seeking worldwide domination in medical research and the development of bio-weapons to target US citizens and our allies,” Westergaard said.
He added, “Alpha Genesis is a leading provider of NHPs to the US market and has been instrumental in attempting to fill this void. The alternative is to allow the Chinese to dominate medical development to the severe detriment of our National Security interests.”
Human error or intentional act?
Asked by ABC News whether the rapid expansion of Alpha Genesis’ breeding and testing operations might have played a role in the escape of the 43 primates, Westergaard said the cause of the escape remains under investigation, including whether it was the result of “human error” or an “intentional act.”
“All the information we have thus far indicates that this is human error due to an employee failing to secure containment doors behind her, and a third door directly containing the animals, while doing routine cleaning and feeding,” Westergaard said in an email. “The enclosure was brand new and in perfect working order. We continue to investigate in an attempt to determine to the greatest extent possible whether this was or was not an intentional act.”
Westergaard said that immediately after the incident occurred, the employee’s supervisor told her she could be fired if it was determined that no structural failure of the primates’ enclosure led to the incident. Westergaard said the employee walked off the job and has not returned.
As of early Tuesday, four of the escaped primates remained on the loose, Westergaard said. Two were caught Monday, he said.
“The girls from today are in good health and the others continue to thrive,” Westergaard said Monday. “We believe the four monkeys remaining are probably all together either in the area adjacent to our property or somewhere else very close by.”
Mace has requested answers from NIH Director Monica Bertagnolli, USDA Deputy Administrator for Animal Care Sarah Helming, and Acting Director Axel Wolf of the NIH’s Office of Laboratory Animal Welfare. She also noted that this was not the first time problems had arisen at the research lab.
Mace, who told ABC News she is against animal testing, cited in her letter a September 2022 USDA inspection report of Alpha Genesis that found six separate incidents of animals escaping from their primary enclosures between January and August of 2022. Mace also cited escapes dating back to 2014, when more than two dozen monkeys slipped out of the facility, resulting in a fine from the USDA.
The 2022 USDA inspection report, which ABC News reviewed, also found an infant monkey died after becoming entangled in a stretch of gauze material used in an enclosure to hold a water bottle; said two primates were found dead in their enclosures with their fingers entrapped in structures inside their cages; and documented that one animal died from trauma and four others required veterinary care after they were placed in incorrect enclosures and were attacked by other primates unfamiliar with them.
As a result of the inspection, Alpha Genesis, according to the report, took corrective action to secure enclosures and “made significant changes” to avoid putting primates in the wrong enclosures.
The latest USDA routine inspection of Alpha Genesis lab was conducted on May 21 and concluded, “No non-compliant items identified during this inspection,” according to USDA online records.
“This is also true of several other inspections in recent years,” Westergaard said. “For a facility of this size that is quite remarkable.”
Mace said she met with Westergaard last week to discuss the escape and what Alpha Genesis is doing to round up the monkeys.
“It was an interesting conversation,” Mace said. “He tried to tell me how good the primates have it at his facility. And my response was, they have it good until you kill them with disease.”
Asked about the conversation, Westergaard responded: “I spoke to the congresswoman last week and at that time she said that she recognized the economic importance of our company to the people of the Low Country and that as a locally-owned business, she would continue to offer her full support.”
Alternatives to testing primates
Angela Grimes, CEO of Born Free USA, an international wildlife conservation and animal protection organization, told ABC News that her group has sent a letter to Alpha Genesis offering to rehome the escaped primates to its animal sanctuary in South Texas, where more than 200 rhesus macaque monkeys now reside, including some rescued from U.S. research labs. She said an anonymous donor has pledged $250,000 to help move the animals to the sanctuary.
“What we’d like to see is these animals be released to the Born Free USA sanctuary in South Texas, where they can have some of that freedom that they’ve just gotten a taste of,” Grimes said.
Grimes said Alpha Genesis has not responded to her group’s offer.
The nonprofit Born Free USA Primate Sanctuary, a 175-acre facility in Dilley, Texas, has been accredited since 2009 by the Global Federation of Animal Sanctuaries, GFAS executive director Valerie Taylor told ABC News, adding that her group conducts rigorous assessments and inspections of animal sanctuaries across the United States and around the globe to ensure the highest standard of animal care possible. Taylor said U.S. animal sanctuaries undergo accreditation every three years and that her organization recently visited the Born Free USA sanctuary as part of the reaccreditation process.
“We meet and exceed GFAS’ highest standards,” Grimes said.
Grimes said the medical research industry needs to research alternatives to subjecting primates to experimental testing of deadly diseases.
“I understand human health is important, but I also look at the other viable alternatives that are out there that do not result in the suffering and death of animals,” Grimes said.
Westergaard said testing of primates is necessary, though.
“There is no safe or effective way to make the leap from simpler model organisms like mice and rats to humans without using NHPs as an intermediary,” Westergaard said. “The therapeutics created using NHPs as research models directly lead to lifesaving and life-prolonging treatments and cures for human disease. Without NHPs as a research model, the world would still be ravaged with wide-spread polio, smallpox wouldn’t be eradicated, and HIV would still be a death sentence.”
(NEW YORK) — A new study is highlighting a dramatic rise in caffeine-related emergency room visits among kids.
The study, released Monday by Epic Research, found the number of caffeine-related ER visits for middle school-aged children nearly doubled from 2017 to 2023, rising from 3.1 per 100,000 visits in 2017 to 6.5 per 100,000 visits in 2023.
For high school-aged children, the rate nearly doubled, rising from 7.5 per 100,000 visits in 2017 to 13.7 per 100,000 visits in 2023, according to the study.
Notably, the study, which looked at more than 223 million ER visits, found that boys had triple the rate of caffeine-related ER visits as girls.
The new study comes less than two months after the release of a report showing a rise in calls to poison centers involving children who consumed energy drinks, which often have high levels of caffeine.
The number of calls to U.S. poison centers about children consuming energy drinks increased about 20% in 2023 after years of remaining relatively flat, according to data from America’s Poison Centers, which accredits and represents 55 poison centers across the country.
Amid the alarming data, here are three things for parents and guardians to know about caffeine and kids.
1. Milk and water are recommended for kids.
Both the U.S. Food and Drug Administration and the American Academy of Pediatrics say water and milk are the best drink options for kids.
The current U.S. dietary guidelines say children under the age of 2 should not have any caffeine. For kids under age 12, caffeine is also not recommended.
It is not known exactly how much caffeine is safe or unsafe for teens or young children, since studies of its effects are not permitted on children.
For adults, the FDA has cited around 400 milligrams of caffeine a day as a generally safe amount, though it notes there is “wide variation” in people’s sensitivity to caffeine.
For reference, a 12-ounce caffeinated soft drink contains anywhere from 23 to 84 milligrams of caffeine, according to the FDA, while a 12-ounce cup of coffee contains 113 to 247 milligrams of caffeine.
2. Caffeine is also in foods, not just drinks.
While caffeine is most often thought of as an ingredient in drinks like coffee, sodas and energy drinks, it is also found in different foods and products, according to the FDA.
Ice cream, chewing gum, protein bars, chocolate chips, energy bars and some over-the-counter medications may also contain caffeine, which has the same effects as when it occurs naturally in drinks like coffee or tea, according to the agency.
Decaffeinated teas and coffees also contain some caffeine.
The FDA recommends reading product ingredient labels carefully to check for caffeine. When it is added to a product, it must be listed on the label as “caffeine.”
When caffeine is naturally in a product, like chocolate, just the caffeine-containing ingredient is listed, according to the FDA.
Multiple signs may indicate a caffeine overdose or poisoning including but not limited to an increased heart rate, heart palpitations, increased blood pressure, nausea or anxiousness. Children with caffeine poisoning may also experience rapid breathing or tremors.
In severe cases, too much caffeine can lead to seizures or cardiac arrest.
In milder cases, too much caffeine can cause dehydration, upset stomach, sleep changes, headaches and jumpiness.
If a child or adult exhibits any such symptoms after consuming a caffeinated drink, they should seek medical attention immediately.
For poisoning-related questions, or if you need emergency assistance, you can contact Poison Help at 1-800-222-1222, or visit PoisonHelp.org.
ABC News’ Youri Benadjaoud contributed to this report.
