These women work to kick colon cancer in ‘Worldclass’ style
GMA
(NEW YORK) — A growing number of people under 50 are being diagnosed with more advanced stages of colon cancer, according to the American Cancer Society.
The 2020 death of 43-year-old actor Chadwick Boseman due to colon cancer drew attention to the shift, and “Dawson’s Creek” star James Van Der Beek, 47, announced his Stage 3 colorectal cancer diagnosis in November.
A diagnosis at a younger age was also the case for Brooks Bell, a Raleigh, North Carolina, entrepreneur who ran a data analytics company. At 38, she was alarmed to discover blood after using the rest room.
She said she called a telehealth doctor, who told her it may be hemorrhoids. She decided to get second and third opinions, which led to a colonoscopy referral and diagnosis.
“I found out that it was Stage 3 colon cancer,” Bell told “GMA3.”
In a different case, Los Angeles stylist Sarah Beran’s doctors suspected a parasite could be causing her symptoms. Ultimately, she said a colonoscopy revealed the truth.
“They found over 100 polyps on my colon, a mass on my rectum,” the 34-year-old said. “And that’s when my world changed.”
She had to undergo a colon transplant and 12 rounds of chemotherapy.
Even though the pair lived on opposite sides of the U.S., their experiences brought them together after Bell shared her story online.
“I reached out and asked her how I could get involved and help, so that more people don’t have to go through what we went through,” Beran said. “And we teamed up.”
The duo dreamed up a fashion brand with a cause, Worldclass. The streetwear and athleisure line includes hoodies, crewneck sweatshirts, tees, hats and totes — all designed to break the stigma about colon cancer.
“All proceeds go towards a colonoscopy fund that helps underinsured communities get screened,” Beran said. “So literally saving lives through fashion.”
Convincing people to get screenings has a specific goal, Bell noted.
“With colon cancer, we should be talking about prevention, being able to avoid the entire cancer experience, period, rather than just talking about early detection,” she said.
A proactive approach to health can make a huge difference, according to Beran.
“A colonoscopy is way easier than going through chemo and the surgeries and all the icky stuff that we went through,” she said. “So we’re lucky that we did catch ours in time and that we did advocate for ourselves. And we got in there and got our colonoscopies. And now we’re here now telling our story.”
(NEW YORK) — From a pig kidney transplant to restoring genetic deafness, 2024 was a year full of medical breakthroughs.
The breakthroughs include the discovery of a cause of an autoimmune disease, the development of a “game-changing” drug and potential hope for those experiencing end-stage organ failure.
Here are five of the biggest highlights in medical achievements this year:
Gene therapy restores hearing in children
Children with hereditary deafness regained their hearing thanks to a type of gene therapy, according to the results of a clinical trial published in the medical journal The Lancet in January.
Investigators from Mass Eye and Ear, a specialty hospital in Boston, examined six children who had a form of genetic deafness called DFNB9, which is caused by a gene mutation that interferes with the transmission of sound signals from the ear to the brain.
Gene therapy involved the use of an inactive virus carrying a functioning version of the gene, which was introduced into the inner ears of the six children.
After 26 weeks, five of the six children recovered their hearing and could even conduct “normal conversation.”
“Children with this genetic hearing loss…the only treatment option for them until now is [a] cochlear implant,” Dr. Zheng-Yi Chen, an associate scientist in the Eaton-Peabody Laboratories at Mass Eye and Ear and study co-investigator, told ABC News. “And of course, [a] cochlear implant can help them tremendously, but it’s with its own limitations.”
“But with this gene therapy, the children regain hearing, and they were able to speak. So, in a way, the life is totally transformed,” he continued. “This study really opened up the whole field that, in the future, we’ll be able to develop a treatment for other [types] of genetic hearing loss, for which there is no treatment at all at the moment.”
Groundbreaking animal organ transplant
Surgeons at Massachusetts General Hospital (MGH) conducted the world’s first genetically-edited pig kidney transplant into a living human in March 2024.
During a four-hour procedure, a surgical team connected the pig kidney’s blood vessels and ureter – the duct that carries urine from the kidney to the bladder – with those of 62-year-old Richard Slayman, a man living with end-stage kidney disease.
“For patients with kidney failure, we know that transplantation is the best treatment option, but unfortunately, we face an immense organ shortage,” Dr. Leonardo Riella, medical director of kidney transplantation at MGH, told ABC News. “So, we have over 100,000 patients waiting for a kidney transplant in the U.S., and more than 17 patients die every day on the waiting list.”
“So, the idea here is, how can we overcome this organ shortage barrier? And having kidneys from another species that could be delivered in a timely manner for these patients once they develop kidney failure could be game-changing for the entire field,” he added.
Slayman passed away in May of this year, but there is no evidence it was the result of the transplant, according to MGH.
Riella said over the course of Slayman’s care, much was learned about how to best deliver care when using animal organs for transplants in the hopes of making the treatment more widely available to patients waiting for a new organ.
A cause of lupus discovered
A team at Brigham & Women’s Hospital and Northwestern Medicine said they have discovered a cause of the autoimmune disease lupus and a possible way to reverse it.
Lupus sees the body’s immune system mistakenly attack its own healthy cells and tissues, which can cause inflammation and damage in organs or systems, according to the Centers for Disease Control and Prevention.
In a study, published in the journal Nature in July, researchers compared blood samples from 19 lupus patients to 19 patients without the condition and found imbalances in the types of T-cells lupus patients produce.
T-cells are a certain type of white blood cell that plays a crucial role in the body’s immune response to the disease.
“We’ve identified a fundamental imbalance in the immune responses that patients with lupus make, and we’ve defined specific mediators that can correct this imbalance to dampen the pathologic autoimmune response,” co-corresponding author Dr. Deepak Rao, a rheumatologist at Brigham and Women’s Hospital and co-director of its Center for Cellular Profiling, said in a press release at the time.
1st new class of schizophrenia drug in more than 3 decades
In September, the FDA approved the first new class of drug to treat people with schizophrenia in more than 30 years.
The pill, called Cobenfy – manufactured by Bristol Myers Squibb – combines two drugs, xanomeline and trospium chloride, and is taken twice a day.
Clinical trials showed the combination helped manage schizophrenia symptoms such as hallucinations, delusions and disorganized thinking.
Dr. René Kahn, chair of psychiatry at the Icahn School of Medicine at Mount Sinai, said it took many years to develop the first medications for schizophrenia, which are effective in preventing psychosis and work by blocking dopamine receptors.
“Blocking the dopamine receptor directly or indirectly is very unpleasant. Sometimes for patients, they can have unpleasant side effects. It can decrease their energy, it can make them feel depressed, and it can give them Parkinsonian side effects,” Kahn told ABC News.
He described Cobenfy as “game-changing in the sense that this is the first drug that doesn’t directly – with the emphasis on directly – influence the dopamine system and certainly doesn’t block dopamine receptors. So that’s very important, because it may show that we don’t have to directly block or affect the dopamine system but can do that through a different mechanism.”
Kahn said the next step will be monitoring the drug as it is prescribed to thousands of schizophrenia patients to ensure it works and that side effects are minimal.
1st over-the-counter combo flu and COVID test outside of emergency use
The FDA authorized the first over-the-counter combination COVID-19 and flu test outside of emergency use in October.
The Healgen Rapid Check COVID-19/Flu A&B Antigen Test can be purchased at a pharmacy or other stores without a prescription.
While there are other over-the-counter combination tests currently available, this is the first to be marketed to consumers using the traditional approval pathway outside of a public health emergency, according to the FDA.
(NEW YORK) — Meta — the company that operates Facebook, Instagram, Threads and WhatsApp –announced on Tuesday it was ending third-party fact-checking.
Some social media policy experts and public health experts are worried that the end of fact-checking could lead to the spread of medical and science misinformation and disinformation. This is especially worrisome as the U.S. is in the throes of respiratory virus season and is fighting the spread of bird flu.
“There’s going to be a rise in all kinds of disinformation, misinformation, from health to hate speech and everything in between,” Megan Squire, deputy director for data analytics and open-source intelligence at the Southern Poverty Law Center, told ABC News. “[Health] is supposed to be a nonpartisan issue, and … we do see people trying to leverage health [misinformation], in particular, toward a political end, and that’s a real shame.”
“I’m hopeful, but I’m also concerned that this new structure that all the Meta properties are embarking on, it’s just not going to end well,” she added.
The social network giant said it was following the footsteps of X, replacing the program with user-added community notes.
In a press release of the announcement, Joel Kaplan, chief global affairs officer for Meta, said that the choices about what was being fact-checked showed “biases and perspectives.”
How fact-checking, community notes work
Meta started fact-checking in December 2016. Meta’s fact-checking works by Meta staff identifying hoaxes or by using technology that detects posts likely to contain misinformation. The fact-checkers then conduct their own reporting to review and rate the accuracy of posts.
If a piece of content is identified as false, it receives a warning label and the content’s distribution is reduced so fewer people see it.
Fact-checkers put in place following Donald Trump’s 2016 election win were found to be “too politically biased” and have destroyed “more trust than they’ve created,” Meta CEO Mark Zuckerberg said in a video posted by the company.
By comparison, community notes work by a user adding context to a post that may be misleading. It is then upvoted or downvoted by other users.
Zeve Sanderson, executive director of NYU Center for Social Media Politics, said after the 2016 election, there was immense pressure for social medial platforms, including Meta, to commit resources to combatting misinformation.
Following the election, most posts being fact-checked were to combat political misinformation, according to Sanderson. During the COVID-19 pandemic, this was expanded to combat medical misinformation, he said.
Sanderson said there were a lot of claims going unchecked online because Meta has not had enough fact-checkers to check every post. Additionally, he said some people didn’t trust fact-checkers.
“There were groups of people online who didn’t trust fact checkers, who saw them as biased, often in a liberal direction,” he told ABC News. “This crowd-sourced content moderation program … it’s going to do different things well and different things poorly. We just don’t know how this is actually going to work in practice.”
Meta referred ABC News back to its Tuesday announcement in response to a request for comment on plans for its community notes or potential spread of misinformation.
Spread of misinformation during COVID-19
During the COVID-19 pandemic, millions were exposed to a deluge of information including news, research, public health guidance and fact sheets, which the World Health Organization referred to as an “infodemic.”
People were also exposed to misinformation and disinformation about what treatments work against COVID-19, how much of a risk the virus poses to children and whether COVID-19 vaccines are effective.
A 2023 KFF survey found that most Americans were not sure if health information they had encountered was true or false.
A report from the U.S. Surgeon General in 2021 found that misinformation led to people rejecting masking and social distancing, using unproven treatment and rejecting COVID-19 vaccines.
Experts told ABC News that members of the general public often do not have enough health literacy to determine if they should trust or not trust information they encounter online or on social media.
Squire said sometimes government agencies do not put out information in an “interesting” format, which may lead people to click on “entertaining” content from misinformation and disinformation peddlers.
“Some of these YouTube videos about health misinformation are a lot more entertaining. Their message just travels faster,” she said. “When you’re presenting scientific information — I know this firsthand as a former college professor — that’s a struggle. You have to be pretty talented at it and, a lot of times, where the expertise lies is not necessarily where the most expedient, fun videos are and stuff.”
How to combat health misinformation
Meta’s change comes as the U.S. faces an increase in bird flu cases and continues treating patients falling ill with respiratory illnesses.
As of Jan. 8, there have been 66 human cases of bird flu reported in the U.S., according to data from the Centers for Disease Control and Prevention.
It’s also flu season. As of the week ending Dec. 28, 2024, there have been at least 5.3 million illnesses, 63,000 hospitalizations and 2,700 deaths from flu so far this season, according to CDC estimates.
Meanwhile, health care professionals have been encouraging Americans to get their flu shot and other vaccines — including COVID and RSV — to protect themselves against serious disease.
Experts are worried that with the change from fact-checking to community notes that misinformation could spread about the effectiveness of vaccines or how serious an illness is.
“I am concerned about the sheer amount of inaccurate information that’s out there,” Dr. Brian Southwell, a distinguished Fellow at nonprofit research institute RTI International and an adjunct faculty member at Duke University, told ABC News. “That’s something that you know ought to bother all of us as we’re trying to make good decisions. But there’s a lot that could be done, even beyond, you know, the realm of social media to try to improve the information environments that are available for people.”
Southwell said one thing that public health experts and federal health agencies can do is to get an idea of the questions that users are going to have about medical topics — such as bird flu and seasonal flu — and be ready with information to answer those questions online.
To combat being exposed to information, the experts recommended paying attention to where the information is coming from, whether it’s a respected source or someone you are unfamiliar with.
“There are various skills that are important, things like lateral reading, where rather than just evaluating the claim, you do research about the source of that claim and what you can find out about them to understand what some of their incentives or track record might be,” Sanderson said.
“This is obviously something that, sadly, social media platforms are not designed in order to incentivize this sort of behavior, so the responsibility is thrust on users to sort of look out for themselves,” he added.
Jessie Owen was left paralyzed nearly 12 years ago when a tree fell on a car in which she was a passenger. Via ABC News.
(NEW YORK) — Nearly 12 years ago, Jessie Owen’s life changed forever.
“My family was going over a mountain pass and a tree fell on our car. In that moment, my parents passed away, my siblings were severely injured, and I became quadriplegic,” Owen said. “I lost my independence. I lost my job. I lost my apartment. I lost my autonomy and the life that I dreamed for myself.”
Like Owen, more than 300,000 people live with spinal cord injuries in the United States, with an estimated 18,000 new cases each year, data shows.
Motor vehicle accidents account for the majority of spinal cord injuries and are closely followed by falls, acts of violence and sports activities, according to the National Spinal Cord Injury Statistical Center.
For years, options for recovery have been limited, but a newly FDA-cleared external spinal stimulator, ARC-EX Therapy, which received clearance on Dec. 19, may offer hope for people like Owen.
“ARC-EX is simply electrodes attached to skin on the back of the neck,” explained Chet Moritz, M.D., a professor of rehabilitation medicine at the University of Washington. “It allows us to pass current through the skin to activate the sensory nerves as they enter the spinal cord. Now, those sensory nerves make direct connections to the motor nerves which help people to move.”
Owen, who participated in the Up-LIFT study, a clinical trial focusing on the health benefits of ARC-EX Therapy, saw a life-changing impact.
“I was wildly surprised and pleased to see that it was making meaningful change in my life. I can now paint with my hands. I can open a jar of peanut butter. I can tie my shoes. It [used to] take me 30 minutes to get dressed. Now it takes 12. [I used to require] 20 caregiving hours a week and I was able to move down to about eight.”
The Up-LIFT study produced promising results.
Of the 60 patients with cervical spinal cord injuries studied, 72% saw improvements in hand strength and function. Participants also reported fewer muscle spasms, better sleep, less pain, and improved independence during daily activities.
“The success of [this] study of people with spinal cord injuries is phenomenal,” noted Moritz. “There are essentially no current therapies for chronic spinal cord injury, and so having the majority of patients respond in both strength and function measures [is] just an outstanding result.”
With FDA approval, ARC-EX Therapy is expected to become more accessible.
“Patients can work with their local rehabilitation clinics to see a therapist and work with them in the clinic at first to tune the device,” Moritz said. Results may appear quickly — some participants noticed changes within just a few sessions, he added.
While the device is currently cleared for improving hand strength, function and sensation, Moritz noted other benefits: “Some people will have modest improvements in their bladder function, heart rate, or blood pressure control.”
Leah Croll, M.D., vascular neurologist at Maimonides Health and assistant professor of neurology at SUNY Downstate, shared the excitement over the device.
“The idea that ARC-EX Therapy may accelerate or augment neurologic recovery is really exciting. Any improvement in neurologic function is meaningful and has far-reaching impact in the daily lives of these patients and their families,” she said.
The road to recovery after a spinal cord injury is grueling, Croll said.
“After emergency and ICU care is completed, the mainstay of treatment is working closely with physical therapists, occupational therapists and other rehabilitation professionals to support neurologic recovery,” said Croll. “Patients may also need medications and certain procedures, depending on their unique symptoms.”
For Owen and others, ARC-EX Therapy represents a renewed sense of hope and an exciting change in the way these patients can be treated.
“[With ARC-EX Therapy], I continued to gain function back, and I found I was able to pour more into other people,” Owen said. “The first indicator of success that I noticed was my own happiness. It works, and it gives us hope and passion.”
Natalie S. Rosen, M.D., is a physician in the Hematology & Oncology Department at New York-Presbyterian Columbia and a member of the ABC News Medical Unit.
