COVID-19 infections during 1st wave linked to higher risk of heart attack and stroke: Study
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(NEW YORK) — People who were diagnosed with severe COVID-19 infections from the first wave of the pandemic could face double the risk of heart attack and stroke, a new study has found.
The study, published this week in the journal Arteriosclerosis, Thrombosis, and Vascular Biology and supported by the National Institutes of Health, found the elevated risk could last for up to three years
Researchers focused on the long-term cardiovascular risks for unvaccinated people who were sick with the virus during the first wave of the COVID-19 pandemic in 2019 and 2020.
Compared to someone who never had COVID-19, the likelihood of heart attack, stroke and death doubled for anyone who was ever ill with the virus, and was four times higher for people who required hospitalization, the study found.
The elevated danger persisted for more than three years after the initial infection, which, according to the study, posed a serious cardiovascular threat comparable to that of type 2 diabetes.
“Findings suggest severe COVID-19 infection as a catastrophic component,” Dr. Hooman Allayee, the study’s principal investigator, told ABC News. “Cardiovascular mortality trends from 2010 to 2019 were steadily going down. Then, all of a sudden, between 2020 and 2022, ten years of work [was] completely wiped out because of COVID-19.”
People with blood types A, B and AB were especially vulnerable to increased cardiovascular risk from COVID-19, while people with type O blood had a reduced chance of facing such issues, according to the study.
“Blood type is known to be associated with heart attack and stroke risk,” said Allayee, who is a professor of population and public health sciences at the Keck School of Medicine at the University of Southern California. “If your blood type is A, B or AB, the virus is more likely to infect you and makes these blood cells open to viral entry.”
The study analyzed individuals from the UK Biobank, a large medical database consisting primarily of data taken from older, wealthier and predominantly white participants. However, similar studies looking at other populations came to nearly identical conclusions, according to Allayee.
The study emphasized the importance of COVID-19 vaccinations, Allayee said.
“No matter what vaccine you got, just six months after the vaccination or the booster, the chance of heart attack and stroke went down,” he said. “But immunity wanes over time, which is why you need the boosters. If not, you could be susceptible to getting severe COVID again.”
Anyone who has ever had a severe COVID-19 infection, especially if they required a hospital stay, should discuss the potentially increased health hazards caused by the virus with their health care provider, Allayee stressed.
“Talk to your doctor and start the discussion with your physician,” he said. “It’s not going away, so we have to start talking about it. Stay on top of your vaccinations and boosters and get regular check-ups.”
Mahir Qureshi, M.D. is an internal medicine physician resident at Cooper University Hospital and a member of the ABC Medical Unit.
(VANCOUVER ISLAND, CANADA) — Police in Canada said they have arrested six people and taken down an organized crime group believed to have produced tens of thousands of counterfeit cannabis-laced candy bars and edibles resembling popular name-brand products.
The takedown began early this month when the Pacific Region Royal Canadian Mounted Police federal policing investigators executed search warrants at two dispensaries and five separate residences on Vancouver Island in British Columbia, Canada, on Oct. 3, according to a statement from the Royal Canadian Mounted Police on Tuesday.
“These warrants were associated to an organized crime group allegedly involved in the production and distribution of illicit drugs, and contraband tobacco in Port Alberni and Nanaimo,” authorities said. “The dispensaries in question were Green Coast Dispensary in Port Alberni and Coastal Storm Dispensary located in Lantzville.”
Search warrants were also executed at a suspected stash site in Port Alberni, as well as a storage and production facility adjacent to Coastal Storm Dispensary, including two modular trailers where cannabis edibles were being produced, stored, and distributed, authorities said.
The list of items seized includes over 120,000 cannabis edibles with packaging resembling popular name-brand chocolate bars, potato chips, nacho chips, honey and other candies, including over 3 kilograms (6.6 pounds) of psilocybin mushrooms, 1,740 psilocybin capsules, over 400 psilocybin chocolate, candies and a multitude of other psilocybin products, 2.2 pounds of pressed cannabis resin, over 500 pounds of cannabis bud, more than 19 pounds of shatter, over 5000 cannabis vape cartridges, counterfeit cannabis-laced honey, five vehicles, two ATM machines containing cash, an estimated 164 master cases of contraband tobacco equating to 82,000 packs of cigarettes, over $400,000 in cash and a shotgun, police said.
“Although the contraband cannabis-laced candy bars and chips resembled professionally manufactured, packaged, and quality-controlled products, they were discovered to have been produced in the highly unsanitary, and heavily contaminated modular trailers,” authorities from RCMP said. “A preliminary assessment of the edibles also indicates that they had been treated with unknown amounts of THC, and likely cross-contaminated with other drugs and substances present in the trailers where they were being produced and packaged.”
Of equal concern, according to police, was the fact that the counterfeit snacks had packaging claims of possessing medicinal properties and dangerously high drug potency values, with many of the candy wrap labels claiming to be “100 times more potent than regulated cannabis products.”
“Given the highly contaminated and unsanitary conditions of the illicit drug production facility where these cannabis edibles were being produced, it is possible that the consumption of these products can lead to serious health risks,” RCMP said. “We urge members of the public to practice extreme caution if they already possess, or come across such products in the future, especially with Halloween being just around the corner.”
This investigation is ongoing and numerous drug-offence-related charges are being pursued.
(YEMASSEE, SC) — With four primates still on the loose after 43 of them escaped on Nov. 6 from the Alpha Genesis Inc. research laboratory in South Carolina, the Low Country facility has come under intense scrutiny.
Animal rights groups have cited the company’s history of violations and previous monkey breakouts; a member of Congress has called for an inquiry into its oversight by multiple federal agencies; and residents voiced concern the furry fugitives might spread disease throughout their community.
On top of it all, Alpha Genesis founder and CEO Gregory Westergaard told ABC News his company is investigating whether the release of the monkeys was “an intentional act” by an employee.
The quest for freedom by the pack of young female rhesus macaques coincides with the rapid expansion of the 100-acre Alpha Genesis facility and is casting light on a disruption in the U.S. medical research industry that sounds like a plot for a science fiction thriller. A 2023 report sponsored by the National Institutes of Health warned of a crisis involving the Chinese government that “undermines the security of the nation’s biomedical research enterprise.”
The case of the absconding primates has also raised questions about why the amount of federal contracts received by the testing and breeding operation has jumped more than 160% since 2021. According to USASpending.gov, a government website that tracks federal spending, the company has been granted $19 million in federal contracts this year alone.
“It’s shocking how much money is being spent on testing primates,” Rep. Nancy Mace, R-S.C., told ABC News.
Mace’s district encompasses the Beaufort County community of Yemassee, where the 6,701 primates housed at the sprawling Alpha Genesis facility nearly triple the number of town residents.
In a formal letter to the NIH, the agency that funds laboratory research, and the U.S. Department of Agriculture, which inspects and regulates breeding facilities, Mace expressed “very urgent concerns regarding federal oversight of Alpha Genesis.” Mace said the prolonged attempts to recapture all of the primates are “placing the animals and my constituents at risk.”
“A lot of constituents were concerned about whether or not the primates that escaped were sick or ill, or have been tested on,” Mace told ABC News. “There were a lot of folks concerned about the facility being a breeding facility and the testing that goes on there as well.”
The escape highlights an ‘issue of national security’
The incident some locals have referred to as “the great escape” has illuminated the international crisis hitting the animal research industry that Alpha Genesis’ Westergaard said has become “an issue of national security.”
In 2020, the Chinese government, the world’s primary breeder of research monkeys, banned the exports of nonhuman primates (NPH) to labs in the United States and elsewhere, triggering an international shortage of the animals just as research scientists were scrambling to come up with vaccines to combat the COVID-19 pandemic, according to a May 2023 report by National Academy of Engineering and National Academy of Medicine.
Primates, according to the NIH-supported report, are valuable in answering certain research questions because of their genetic, anatomic, physiologic and behavioral similarities to humans. However, the China ban on exporting research animals exacerbated the shortage and stalled NIH-funded research, according to the report.
The report concluded that the United States “needs to prioritize expansion” of domestic primate breeding programs.
“Relying on importing these animals from other countries is unsustainable, and dependence on international sources undermines the security of the nation’s biomedical research enterprise,” the report warned.
In 2021, the National Primate Research Centers could not meet two-thirds of researcher requests for rhesus macaques, according to the report.
“Researchers also face increased wait times for animals, and costs have risen 10% to 200% for a single animal, depending on the species,” the report said.
What we know about Alpha Genesis’ research
The crisis prompted Alpha Genesis to increase its domestic breeding of research primates. According to Rep. Mace, the company also manages the NIH’s so-called “Monkey Island” on Morgan Island in Beaufort County, which holds another 3,300 primates.
Westergaard told ABC News that Alpha Genesis employs 275 people, plus 30 or so contractors.
In addition to breeding lab monkeys, Alpha Genesis provides researchers across the country with biological products and materials, including serum, plasma, whole blood and tissue samples from a wide variety of research species, according to the company’s website. The private company’s researchers have helped develop several therapeutic drugs and vaccines, including those to treat the COVID-19 virus.
According to NIH online records provided to USASpending.gov, the crisis appears to be in accord with a boost in federal contracts Alpha Genesis has received, jumping from $7.3 million in 2021 to $12.3 million in 2022, $14.2 million in 2023 and $19 million this year.
Primates are worth up to $30,000 each
“The price of research monkeys has indeed increased a great deal since the Chinese banned all exports,” Westergaard said in an email to ABC News. “Prior to the ban monkeys sold for around $4K – $6K, after the ban prices have increased to $10K – $30K+ due to increased costs of raising animals in the US compared to China. An important point to note is that the shortage remains severe and a great deal of research in the US simply cannot be done because animals are not available at any cost.”
Westergaard said some suppliers of laboratory primates have turned to the illegal sourcing of wild-caught monkeys from Cambodia, “which we have not done.”
“It should also be noted that the Chinese government is seeking worldwide domination in medical research and the development of bio-weapons to target US citizens and our allies,” Westergaard said.
He added, “Alpha Genesis is a leading provider of NHPs to the US market and has been instrumental in attempting to fill this void. The alternative is to allow the Chinese to dominate medical development to the severe detriment of our National Security interests.”
“It should also be noted that the Chinese government is seeking worldwide domination in medical research and the development of bio-weapons to target US citizens and our allies,” Westergaard said.
He added, “Alpha Genesis is a leading provider of NHPs to the US market and has been instrumental in attempting to fill this void. The alternative is to allow the Chinese to dominate medical development to the severe detriment of our National Security interests.”
Human error or intentional act?
Asked by ABC News whether the rapid expansion of Alpha Genesis’ breeding and testing operations might have played a role in the escape of the 43 primates, Westergaard said the cause of the escape remains under investigation, including whether it was the result of “human error” or an “intentional act.”
“All the information we have thus far indicates that this is human error due to an employee failing to secure containment doors behind her, and a third door directly containing the animals, while doing routine cleaning and feeding,” Westergaard said in an email. “The enclosure was brand new and in perfect working order. We continue to investigate in an attempt to determine to the greatest extent possible whether this was or was not an intentional act.”
Westergaard said that immediately after the incident occurred, the employee’s supervisor told her she could be fired if it was determined that no structural failure of the primates’ enclosure led to the incident. Westergaard said the employee walked off the job and has not returned.
As of early Tuesday, four of the escaped primates remained on the loose, Westergaard said. Two were caught Monday, he said.
“The girls from today are in good health and the others continue to thrive,” Westergaard said Monday. “We believe the four monkeys remaining are probably all together either in the area adjacent to our property or somewhere else very close by.”
Mace has requested answers from NIH Director Monica Bertagnolli, USDA Deputy Administrator for Animal Care Sarah Helming, and Acting Director Axel Wolf of the NIH’s Office of Laboratory Animal Welfare. She also noted that this was not the first time problems had arisen at the research lab.
Mace, who told ABC News she is against animal testing, cited in her letter a September 2022 USDA inspection report of Alpha Genesis that found six separate incidents of animals escaping from their primary enclosures between January and August of 2022. Mace also cited escapes dating back to 2014, when more than two dozen monkeys slipped out of the facility, resulting in a fine from the USDA.
The 2022 USDA inspection report, which ABC News reviewed, also found an infant monkey died after becoming entangled in a stretch of gauze material used in an enclosure to hold a water bottle; said two primates were found dead in their enclosures with their fingers entrapped in structures inside their cages; and documented that one animal died from trauma and four others required veterinary care after they were placed in incorrect enclosures and were attacked by other primates unfamiliar with them.
As a result of the inspection, Alpha Genesis, according to the report, took corrective action to secure enclosures and “made significant changes” to avoid putting primates in the wrong enclosures.
The latest USDA routine inspection of Alpha Genesis lab was conducted on May 21 and concluded, “No non-compliant items identified during this inspection,” according to USDA online records.
“This is also true of several other inspections in recent years,” Westergaard said. “For a facility of this size that is quite remarkable.”
Mace said she met with Westergaard last week to discuss the escape and what Alpha Genesis is doing to round up the monkeys.
“It was an interesting conversation,” Mace said. “He tried to tell me how good the primates have it at his facility. And my response was, they have it good until you kill them with disease.”
Asked about the conversation, Westergaard responded: “I spoke to the congresswoman last week and at that time she said that she recognized the economic importance of our company to the people of the Low Country and that as a locally-owned business, she would continue to offer her full support.”
Alternatives to testing primates
Angela Grimes, CEO of Born Free USA, an international wildlife conservation and animal protection organization, told ABC News that her group has sent a letter to Alpha Genesis offering to rehome the escaped primates to its animal sanctuary in South Texas, where more than 200 rhesus macaque monkeys now reside, including some rescued from U.S. research labs. She said an anonymous donor has pledged $250,000 to help move the animals to the sanctuary.
“What we’d like to see is these animals be released to the Born Free USA sanctuary in South Texas, where they can have some of that freedom that they’ve just gotten a taste of,” Grimes said.
Grimes said Alpha Genesis has not responded to her group’s offer.
The nonprofit Born Free USA Primate Sanctuary, a 175-acre facility in Dilley, Texas, has been accredited since 2009 by the Global Federation of Animal Sanctuaries, GFAS executive director Valerie Taylor told ABC News, adding that her group conducts rigorous assessments and inspections of animal sanctuaries across the United States and around the globe to ensure the highest standard of animal care possible. Taylor said U.S. animal sanctuaries undergo accreditation every three years and that her organization recently visited the Born Free USA sanctuary as part of the reaccreditation process.
“We meet and exceed GFAS’ highest standards,” Grimes said.
Grimes said the medical research industry needs to research alternatives to subjecting primates to experimental testing of deadly diseases.
“I understand human health is important, but I also look at the other viable alternatives that are out there that do not result in the suffering and death of animals,” Grimes said.
Westergaard said testing of primates is necessary, though.
“There is no safe or effective way to make the leap from simpler model organisms like mice and rats to humans without using NHPs as an intermediary,” Westergaard said. “The therapeutics created using NHPs as research models directly lead to lifesaving and life-prolonging treatments and cures for human disease. Without NHPs as a research model, the world would still be ravaged with wide-spread polio, smallpox wouldn’t be eradicated, and HIV would still be a death sentence.”
(NEW YORK) — A rise in rates of sudden unexpected infant deaths may have been linked to an off-season surge of respiratory syncytial virus (RSV) in 2021, according to a new study published Thursday in the journal JAMA Open Network.
Sudden unexpected infant deaths (SUID) includes deaths of infants under one year old without a known cause, deaths that are due to accidental suffocation or strangulation in bed and those from sudden infant death syndrome (SIDS), according to the Centers for Disease Control and Prevention (CDC).
“This is an important topic because SIDS and other unexpected deaths are still one of the leading causes of infant mortality, and there’s still a lot unknown,” said Dr. John Brownstein, an epidemiologist and chief innovation officer at Boston Children’s Hospital and an ABC News contributor.
The most recent CDC data shows about 3,700 infants died from SUID in 2022 and 41% were from SIDS.
“There are very few things that are as horrific as a family experiencing a sudden infant death, and especially given the causes are so often unknown,” Brownstein said.
Using records from the CDC, researchers analyzed more than 14,000 cases of SUID and found that rates per 100,000 live births increased by 10% from 2019 to 2021.
Results showed the risk of SUID was highest from June to December 2021 — at the same time there was an off-season surge in hospitalizations due to RSV after the virus skipped its typical winter season in 2020.
Influenza hospitalizations were rare during this time and hospitalizations from COVID-19 did not have any clear association with monthly changes in SUID rates in the study.
These findings may indicate a connection between the risk of SUID and seasonal shifts in infections like RSV, but more research is needed to better understand this link.
“The findings underscore the importance of monitoring infant mortality during and after pandemics and obviously it puts big support for vaccinations and RSV prevention,” Brownstein said.
Currently, there are newer RSV shots available that doctors say are important to help prevent RSV and give babies the best protection against this virus that hospitalizes thousands of kids a year, mostly babies.
The American College of Obstetricians and Gynecologists recommends pregnant women get an RSV vaccine between 32 and 36 weeks of pregnancy to pass on antibody protection to newborns.
The CDC recommends an RSV antibody shot called nirsevimab for all babies less than 8 months old unless their mother received an RSV vaccine in pregnancy at least 2 weeks before birth.
While nirsevimab had supply constraints last year in its first season, Sanofi, the drug manufacturer, recently announced they have started shipping shots to doctors’ offices and anticipate having enough doses for all eligible babies in the US this RSV season.
Doctors say safe sleep is also important for SUID prevention. The American Academy of Pediatrics recommends that infants sleep alone, placed down on their back on a firm, flat surface, with nothing in the sleeping area other than a fitted sheet.
Scott Gummerson, MD, ScM, is an emergency medicine resident and member of the ABC Medical News Unit.
Jade A. Cobern, MD, MPH is a physician board-certified in pediatrics and preventive medicine and a medical fellow of the ABC News Medical Unit.
