Respiratory virus activity is ‘high’ as cases increase in US: CDC
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(NEW YORK) — Respiratory illness activity – a measure of how often conditions like the common cold, flu, COVID-19, and respiratory syncytial virus are diagnosed – is currently “high” in the United States, according to an update from the Centers for Disease Control and Prevention.
Currently, New Hampshire is listed as having “very high” respiratory virus activity, and 11 states – Arizona, Delaware, Georgia, Idaho, Kansas, Kentucky, Louisiana, Oklahoma, Tennessee, Texas and Wisconsin – are listed as having “high” activity, CDC data shows.
Meanwhile, 29 states are listed as having “moderate” activity, and the remaining states are listed as having “low” activity.
Particularly, COVID-19, seasonal flu and RSV activity are increasing across the country with a rising number of people visiting emergency departments and the number of tests coming back positive for one of the three conditions, the CDC said.
The CDC estimates that there have been at least 3.1 million illnesses, 37,000 hospitalizations and 1,500 deaths from flu so far this season; these figures are based on the latest date for which data is available, which is the week ending Dec. 21.
Five pediatric deaths were reported during the week of Dec. 21, bringing the total number to nine so far during the 2024-25 season.
The CDC says levels of the COVID-19 virus being detected in wastewater are increasing, as are the number of emergency department visits and laboratory test positivity rates.
“Based on CDC modeled estimates of epidemic growth, we predict COVID-19 illness will continue to increase in the coming weeks as it usually does in the winter,” the CDC said in a statement.
For RSV, the CDC said emergency department visits and hospitalizations are increasing among children and hospitalizations are increasing among older adults in some areas.
Flu and COVID-19 vaccines are available for both children and adults, and RSV vaccines are available for certain groups of adults. However, vaccination coverage remains low, meaning “many children and adults lack protection from respiratory virus infections provided by vaccines,” according to the CDC.
As of Dec. 21, only 41.9% of adults were vaccinated against the flu and 21.4% were vaccinated with the updated 2024-25 COVID-19 vaccine. Additionally, just 43.7% of adults ages 75 and older have received the RSV vaccine, according to CDC data.
Nearly half of all children are vaccinated against the flu at 42.5%, but just 10.3% have received the updated COVID-19 vaccine.
(NEW YORK) — From a pig kidney transplant to restoring genetic deafness, 2024 was a year full of medical breakthroughs.
The breakthroughs include the discovery of a cause of an autoimmune disease, the development of a “game-changing” drug and potential hope for those experiencing end-stage organ failure.
Here are five of the biggest highlights in medical achievements this year:
Gene therapy restores hearing in children
Children with hereditary deafness regained their hearing thanks to a type of gene therapy, according to the results of a clinical trial published in the medical journal The Lancet in January.
Investigators from Mass Eye and Ear, a specialty hospital in Boston, examined six children who had a form of genetic deafness called DFNB9, which is caused by a gene mutation that interferes with the transmission of sound signals from the ear to the brain.
Gene therapy involved the use of an inactive virus carrying a functioning version of the gene, which was introduced into the inner ears of the six children.
After 26 weeks, five of the six children recovered their hearing and could even conduct “normal conversation.”
“Children with this genetic hearing loss…the only treatment option for them until now is [a] cochlear implant,” Dr. Zheng-Yi Chen, an associate scientist in the Eaton-Peabody Laboratories at Mass Eye and Ear and study co-investigator, told ABC News. “And of course, [a] cochlear implant can help them tremendously, but it’s with its own limitations.”
“But with this gene therapy, the children regain hearing, and they were able to speak. So, in a way, the life is totally transformed,” he continued. “This study really opened up the whole field that, in the future, we’ll be able to develop a treatment for other [types] of genetic hearing loss, for which there is no treatment at all at the moment.”
Groundbreaking animal organ transplant
Surgeons at Massachusetts General Hospital (MGH) conducted the world’s first genetically-edited pig kidney transplant into a living human in March 2024.
During a four-hour procedure, a surgical team connected the pig kidney’s blood vessels and ureter – the duct that carries urine from the kidney to the bladder – with those of 62-year-old Richard Slayman, a man living with end-stage kidney disease.
“For patients with kidney failure, we know that transplantation is the best treatment option, but unfortunately, we face an immense organ shortage,” Dr. Leonardo Riella, medical director of kidney transplantation at MGH, told ABC News. “So, we have over 100,000 patients waiting for a kidney transplant in the U.S., and more than 17 patients die every day on the waiting list.”
“So, the idea here is, how can we overcome this organ shortage barrier? And having kidneys from another species that could be delivered in a timely manner for these patients once they develop kidney failure could be game-changing for the entire field,” he added.
Slayman passed away in May of this year, but there is no evidence it was the result of the transplant, according to MGH.
Riella said over the course of Slayman’s care, much was learned about how to best deliver care when using animal organs for transplants in the hopes of making the treatment more widely available to patients waiting for a new organ.
A cause of lupus discovered
A team at Brigham & Women’s Hospital and Northwestern Medicine said they have discovered a cause of the autoimmune disease lupus and a possible way to reverse it.
Lupus sees the body’s immune system mistakenly attack its own healthy cells and tissues, which can cause inflammation and damage in organs or systems, according to the Centers for Disease Control and Prevention.
In a study, published in the journal Nature in July, researchers compared blood samples from 19 lupus patients to 19 patients without the condition and found imbalances in the types of T-cells lupus patients produce.
T-cells are a certain type of white blood cell that plays a crucial role in the body’s immune response to the disease.
“We’ve identified a fundamental imbalance in the immune responses that patients with lupus make, and we’ve defined specific mediators that can correct this imbalance to dampen the pathologic autoimmune response,” co-corresponding author Dr. Deepak Rao, a rheumatologist at Brigham and Women’s Hospital and co-director of its Center for Cellular Profiling, said in a press release at the time.
1st new class of schizophrenia drug in more than 3 decades
In September, the FDA approved the first new class of drug to treat people with schizophrenia in more than 30 years.
The pill, called Cobenfy – manufactured by Bristol Myers Squibb – combines two drugs, xanomeline and trospium chloride, and is taken twice a day.
Clinical trials showed the combination helped manage schizophrenia symptoms such as hallucinations, delusions and disorganized thinking.
Dr. René Kahn, chair of psychiatry at the Icahn School of Medicine at Mount Sinai, said it took many years to develop the first medications for schizophrenia, which are effective in preventing psychosis and work by blocking dopamine receptors.
“Blocking the dopamine receptor directly or indirectly is very unpleasant. Sometimes for patients, they can have unpleasant side effects. It can decrease their energy, it can make them feel depressed, and it can give them Parkinsonian side effects,” Kahn told ABC News.
He described Cobenfy as “game-changing in the sense that this is the first drug that doesn’t directly – with the emphasis on directly – influence the dopamine system and certainly doesn’t block dopamine receptors. So that’s very important, because it may show that we don’t have to directly block or affect the dopamine system but can do that through a different mechanism.”
Kahn said the next step will be monitoring the drug as it is prescribed to thousands of schizophrenia patients to ensure it works and that side effects are minimal.
1st over-the-counter combo flu and COVID test outside of emergency use
The FDA authorized the first over-the-counter combination COVID-19 and flu test outside of emergency use in October.
The Healgen Rapid Check COVID-19/Flu A&B Antigen Test can be purchased at a pharmacy or other stores without a prescription.
While there are other over-the-counter combination tests currently available, this is the first to be marketed to consumers using the traditional approval pathway outside of a public health emergency, according to the FDA.
(LUBBOCK, Texas) — An unvaccinated school-aged child in Texas has died of measles, the first associated with an outbreak in the western part of the state that has infected more than 100 people.
Lubbock city spokesperson Lauren Adams confirmed the death to ABC News on Wednesday.
In a press release, the Texas Department of State Health Services (DSHS) said the child was hospitalized in Lubbock, located in northwestern Texas, last week and tested positive for measles.
As of Wednesday, 124 cases of measles have been confirmed, according to data from DSHS.
Almost all of the cases are in unvaccinated individuals or individuals whose vaccination status is unknown, and 18 people have been hospitalized so far, DSHS said.
Children and teenagers between ages 5 and 17 make up the majority of cases with 62, followed by 39 cases among children ages 4 and under.
This is a developing story. Please check back for updates.
(LOS ANGELES) — As devastating wildfires continue to spread across southern California, thousands of structures have been destroyed or damaged and at least five people have been killed.
Residents and firefighters have suffered physical injuries, but doctors say the wildfires can also take a heavy mental health toll on civilians and first responders.
“I think when disaster like this is unfolding, it makes sense to prioritize people’s lives and mortality but, over time, we have to think about mental health consequences too,” Dr. Sarah Lowe, associate professor of social and behavioral sciences at Yale School of Public Health, told ABC News.
“We also know that mental and physical health are connected,” she continued. “While mental health symptoms might not necessarily be linked to the exposure itself, they could be linked to or exacerbated by physical health ailments.”
Mental health experts say that most people are resilient and do not develop a mental health condition as a result of trauma from a natural disaster.
However, those with more exposure to the event — such as losing a home, losing a loved one or experiencing injury — are at higher risk, the experts said.
“It is common to experience emotional distress during these traumatic events, where people often lose a sense of control,” Dr. Jace Reed, director of emergency psychiatry for the department of psychiatry & behavioral neurosciences at Cedars-Sinai in Los Angeles, told ABC News. “The current wildfires have led to evacuations, the destruction of homes and property, the loss of beloved pets, physical injuries and even death, all of which can be profoundly distressing.
“Individuals may feel a range of emotions, including denial, anger, sadness, shock and hopelessness,” he added. “This emotional response can evolve into later stages, such as acceptance, further sadness, depression and bitterness.”
Research has shown wildfires can lead to increased rates of anxiety and depression and symptoms may become worse among people who already have these conditions.
Additionally, people can develop post-traumatic stress disorder (PTSD), which can include intrusive thoughts and nightmares.
Leaving PTSD untreated can result in the use of or dependence on drugs and alcohol, increased risk of chronic health conditions and increased risk of self-harm.
Dr. Ian Stanley, an assistant professor in the Department of Emergency Medicine at the University of Colorado School of Medicine, told ABC News that untreated PTSD can put a strain on relationships including familial relationships, romantic relationships and friendships.
“It can really begin to eat away at, not just the person’s well-being, but also the social environment in which they live,” he said.
Wildfire smoke can also put you at risk
The experts said it’s not just people directly affected by the fire who are at risk of mental health impacts. People exposed to wildfire smoke are at risk as well.
Wildfire smoke can travel long distances, meaning cities hundreds of miles away may be experiencing unhealthy air quality.
A 2024 study from Emory University found that wildfire smoke was linked with emergency department visits for anxiety disorders with higher risks among girls, women and older adults.
“Even people who aren’t directly affected by fires, the smoke from them, coming into their neighborhoods and communities, even if it’s imperceptible, can have impacts on mental health,” Lowe said. “We’re seeing more and more, and that’s with a range of mental health conditions, including depression, anxiety.”
Firefighters, first responders also at risk
Firefighters battling the flames and first responders helping treat those who are injured or are in need are also at risk of experiencing mental health impacts.
Firefighters and other rescue personnel are at greater risk of developing PTSD compared to the general population. An August 2016 study found approximately 20% of firefighters and paramedics meet the criteria for PTSD at some point in their career compared to a 6.8% lifetime risk for the general population, according to the U.S. Fire Administration.
“They’re on the front lines, and first responders, firefighters, police, EMS have potentially pre-existing vulnerabilities to developing mental health problems at a higher rate than the civilian population,” Stanley said.
The duties of first responders — facing challenging situations, reaching out to survivors, providing support — can be strenuous and put them at an increased risk of trauma, according to a 2018 report from the Substance Abuse and Mental Health Services Administration.
“They’re trained to do this; this is their job, and yet it can still take a toll on them, especially the crews that are away from home, spending weeks away from home and maybe lacking the traditional support system that are used to,” Stanley said.
How to help those with mental health impacts
Lowe said it will be important for California to make sure it is providing enough licensed professionals to the areas where people may be in need.
This can be challenging in the face of a large-scale mental health crisis in the U.S. in which there is a shortage of mental health professionals.
“Having good coverage for mental health services, increasing access to services” is important, she said. “A lot of times, we can’t practice outside of our jurisdiction, but there’s declarations during disasters, folks can practice outside … so just ways to increase access.”
The experts also recommend limiting time reading news coverage and social media posts of the wildfires, much of which can be distressing.
“This can lead to increased anxiety, sleep difficulties and stress, causing many people to feel the urge to consume more information,” Reed said. This increased consumption is likely more anxiety-provoking than comforting. … I recommend that people consume this content in moderation and focus on activities that help reduce their stress levels.”
Family members and friends can help by providing a sense of support for their loved one and confidently checking in, the experts said.
“You can think of kind of the 3 Hs here: Do you want to be helped? Do you want to be hugged? Or do you want to be heard?” Stanley said. “Some people just want a shoulder to cry on. Some people want you to go into problem-solving mode and some people just want a listening ear.”
